Haematopoietic stem cells (HSCs) are a self-renewing population of cells that continuously
replenish all blood and immune cells during the lifetime of an individual,. HSCs are used …

The basic-helix-loop-helix (bHLH) proteins are a superfamily of DNA-binding transcription
factors that regulate numerous biological processes in both invertebrates and vertebrates …

The SCL gene encodes a basic helix–loop–helix (bHLH) transcription factor that is essential
for the development of all haematopoietic lineages. SCL is also expressed in endothelial …

The neuron-restrictive silencer factor (NRSF) represses transcription of several neuronal
genes in nonneuronal cells by binding to a 21-bp element called the neuron-restrictive …

Wnts are secreted signaling molecules implicated in various developmental processes and
frizzled proteins are the receptors for these Wnt ligands. To investigate the physiological …

Upon ligand binding, the receptors of the TGFβ family phosphorylate Smad proteins, which
then move into the nucleus where they activate transcription. To carry out this function, the …

The mammalian habenula consists of the medial and lateral habenulae. Recent behavioral
and electrophysiological studies suggested that the lateral habenula plays a pivotal role in …

We have identified Math5, a mouse basic helix-loop-helix (bHLH) gene that is closely
related to Drosophila atonal and Xenopus Xath5 and is largely restricted to the developing …

Oligodendrocytes are produced from the same region of the ventral spinal cord that earlier
generated motor neurons in bird and rodent embryos. Motor neuron and oligodendrocyte …

In the sea urchin embryo, the oral-aboral axis is specified after fertilization by mechanisms
that are largely unknown. We report that early sea urchin embryos express Nodal and …