Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Small RNAs (also referred to as small noncoding RNAs, sncRNA) are defined as polymeric
ribonucleic acid molecules that are less than 200 nucleotides in length and serve a variety of …

Chemical modifications of RNA molecules regulate both RNA metabolism and fate. The
deposition and function of these modifications are mediated by the actions of writer, reader …

Background Musculoskeletal disorder (MSD) are a class of inflammatory and degener‐ative
diseases, but the precise molecular mechanisms are still poorly understood. Noncoding …

N6-methyladenosine (m6A) is the most common and conserved internal eukaryotic mRNA
modification. m6A modification is a dynamic and reversible post-transcriptional regulatory …

The proper transfer of genetic information from DNA to RNA to protein is essential for cell-
fate control, development, and health. Methylation of DNA, RNAs, histones, and non-histone …

Low back pain (LBP) is one of the most common health problems in people's lives, which
brings a massive burden to clinicians, and the leading cause of LBP is intervertebral disc …

Intervertebral disc (IVD) degeneration is the leading cause of low back pain, which has a
striking impact on numerous patients. Therefore, comprehensively illuminating the …

Intervertebral disc degeneration (IVDD) is the main cause of cervical and lumbar
spondylosis. Over the past few years, the relevance between cellular senescence and IVDD …

Methylation is the most common posttranscriptional modification in cellular RNAs, which has
been reported to modulate the alteration of RNA structure for initiating relevant functions …