Global trends in hepatocellular carcinoma epidemiology: implications for screening, prevention and therapy

AG Singal, F Kanwal, JM Llovet - Nature reviews Clinical oncology, 2023 - nature.com
Hepatocellular carcinoma (HCC) mortality rates are increasing globally, and particularly in
the Western world. Cirrhosis remains the predominant risk factor for HCC. However …

[HTML][HTML] Epidemiology of liver cirrhosis and associated complications: Current knowledge and future directions

YB Liu, MK Chen - World journal of gastroenterology, 2022 - ncbi.nlm.nih.gov
Cirrhosis causes a heavy global burden. In this review, we summarized up-to-date
epidemiological features of cirrhosis and its complications. Recent epidemiological studies …

Risk stratification and early detection biomarkers for precision HCC screening

YT Lee, N Fujiwara, JD Yang, Y Hoshida - Hepatology, 2023 - journals.lww.com
Hepatocellular carcinoma (HCC) mortality remains high primarily due to late diagnosis as a
consequence of failed early detection. Professional societies recommend semi‐annual HCC …

MAFLD: an optimal framework for understanding liver cancer phenotypes

H Crane, C Gofton, A Sharma, J George - Journal of Gastroenterology, 2023 - Springer
Hepatocellular carcinoma has a substantial global mortality burden which is rising despite
advancements in tackling the traditional viral risk factors. Metabolic (dysfunction) associated …

Hepatocellular carcinoma prevention in the era of hepatitis C elimination

JV Lazarus, CA Picchio, M Colombo - International Journal of Molecular …, 2023 - mdpi.com
The hepatitis C virus (HCV), a single-stranded RNA virus belonging to the Flaviviridae
family, is a major cause of hepatocellular carcinoma (HCC) worldwide. Tumors caused by …

Cell senescence in liver diseases: pathological mechanism and theranostic opportunity

D Sanfeliu-Redondo, A Gibert-Ramos… - Nature Reviews …, 2024 - nature.com
The liver is not oblivious to the passage of time, as ageing is a major risk factor for the
development of acute and chronic liver diseases. Ageing produces alterations in all hepatic …

[HTML][HTML] Statistical perspectives on using hepatocellular carcinoma risk models to inform surveillance decisions

H Innes, P Nahon - Journal of hepatology, 2023 - Elsevier
More than 50,000 people are diagnosed with hepatocellular carcinoma (HCC) every year in
Europe. Many cases are known to specialist liver centres years before they present with …

Changing epidemiology of hepatocellular carcinoma within the United States and worldwide

NE Rich - Surgical Oncology Clinics, 2024 - surgonc.theclinics.com
Hepatocellular carcinoma (HCC), the most common type of primary liver cancer, is the third
most common cause of cancer-related death worldwide and a leading cause of death in …

Hepatocellular Carcinoma Diagnosis and Management in 2021: A National Veterans Affairs Quality Improvement Project

SS Rogal, TH Taddei, A Monto, V Yakovchenko… - Clinical …, 2024 - Elsevier
Background & Aims The coronavirus disease–2019 pandemic profoundly disrupted
preventative health care services including cancer screening. As the largest provider of …

Incidence and risk factors of hepatocellular carcinoma in patients with chronic hepatitis C treated with direct-acting antivirals

C Leal, J Strogoff-de-Matos, C Theodoro, R Teixeira… - Viruses, 2023 - mdpi.com
Background: Conflicting data regarding the incidence of hepatocellular carcinoma (HCC)
after cure of HCV infection with direct-acting antivirals (DAAs) remains. We investigated the …