Food allergy, mechanisms, diagnosis and treatment: Innovation through a multi‐targeted approach

SB Sindher, A Long, AR Chin, A Hy, V Sampath… - Allergy, 2022 - Wiley Online Library
The incidence of food allergy (FA) has continued to rise over the last several decades,
posing significant burdens on health and quality of life. Significant strides into the …

Risk of second allergic reaction to SARS-CoV-2 vaccines: a systematic review and meta-analysis

DK Chu, EM Abrams, DBK Golden… - JAMA internal …, 2022 - jamanetwork.com
Importance Vaccination against SARS-CoV-2 is a highly effective strategy to prevent
infection and severe COVID-19 outcomes. The best strategy for a second dose of vaccine …

Updating the CoFAR grading scale for systemic allergic reactions in food allergy

RS Chinthrajah, SM Jones, EH Kim, SH Sicherer… - Journal of Allergy and …, 2022 - Elsevier
Background Immunotherapy is promising as an efficacious treatment for food allergy. Other
food allergy treatments are also under development. However, adverse allergic events …

Management of IgE‐mediated food allergy in the 21st century

A Cafarotti, M Giovannini, P Begìn… - Clinical & …, 2023 - Wiley Online Library
The 21st century has seen the propulsion of research in the field of food allergy, which has
driven real changes in the clinical approach. Allergen immunotherapy has been …

Diagnostic accuracy of vaccine and vaccine excipient testing in the setting of allergic reactions to COVID‐19 vaccines: a systematic review and meta‐analysis

M Greenhawt, M Shaker, DBK Golden, EM Abrams… - Allergy, 2023 - Wiley Online Library
For persons with immediate allergic reactions to mRNA COVID‐19 vaccines, skin testing
(ST) to the vaccine/excipients (polyethylene glycol [PEG] and polysorbate 80 [PS]) has been …

Food-dependent exercise-induced wheals, angioedema, and anaphylaxis: a systematic review

K Kulthanan, P Ungprasert… - The Journal of Allergy …, 2022 - Elsevier
Background Food-dependent exercise-induced wheals, angioedema, and anaphylaxis
remain insufficiently characterized. Objective We systematically reviewed the literature on …

Pathophysiological, cellular, and molecular events of the vascular system in anaphylaxis

E Nuñez-Borque, S Fernandez-Bravo… - Frontiers in …, 2022 - frontiersin.org
Anaphylaxis is a systemic hypersensitivity reaction that can be life threatening.
Mechanistically, it results from the immune activation and release of a variety of mediators …

Platelet‐activating factor acetylhydrolase is a biomarker of severe anaphylaxis in children

JEM Upton, JA Hoang, M Leon‐Ponte, Y Finkelstein… - Allergy, 2022 - Wiley Online Library
Background There is limited ability to predict the severity of allergic reactions in children.
Data derived predominantly from adults have implicated the platelet‐activating factor …

Anaphylaxis knowledge gaps and future research priorities: a consensus report

TE Dribin, D Schnadower, J Wang… - Journal of Allergy and …, 2022 - Elsevier
Background Despite a better understanding of the epidemiology, pathogenesis, and
management of patients with anaphylaxis, there remain knowledge gaps. Enumerating and …

Development and validation of the food allergy severity score

M Fernández‐Rivas, I Gómez García… - Allergy, 2022 - Wiley Online Library
Background The heterogeneity and lack of validation of existing severity scores for food
allergic reactions limit standardization of case management and research advances. We …