The unique properties of IgG4 and its roles in health and disease

T Rispens, MG Huijbers - Nature Reviews Immunology, 2023 - nature.com
IgG4 is the least abundant subclass of IgG in human serum and has unique functional
features. IgG4 is largely unable to activate antibody-dependent immune effector responses …

[HTML][HTML] Multivalent protein-drug conjugates–An emerging strategy for the upgraded precision and efficiency of drug delivery to cancer cells

N Porębska, K Ciura, A Chorążewska… - Biotechnology …, 2023 - Elsevier
With almost 20 million new cases per year, cancer constitutes one of the most important
challenges for public health systems. Unlike traditional chemotherapy, targeted anti-cancer …

High-Performance Plasma Biomarker Panel for Alzheimer's Disease Screening Using a Femtomolar-Level Label-Free Biosensing System

S Wang, R Deng, Z Chen, L Huang, Y Song, D Yuan… - ACS …, 2023 - ACS Publications
Alzheimer's disease (AD) is the most common cause of dementia in older people. However,
diagnosing AD through noncognitive methods, such as invasive cerebrospinal fluid …

Optofluidic tweezers: efficient and versatile micro/nano-manipulation tools

Y Zhu, M You, Y Shi, H Huang, Z Wei, T He, S Xiong… - Micromachines, 2023 - mdpi.com
Optical tweezers (OTs) can transfer light momentum to particles, achieving the precise
manipulation of particles through optical forces. Due to the properties of non-contact and …

Antibody-dependent enhancement:″Evil ″antibodies favorable for viral infections

X Yang, X Zhang, X Zhao, M Yuan, K Zhang, J Dai… - Viruses, 2022 - mdpi.com
The pandemics caused by emerging viruses such as severe acute respiratory syndrome
coronavirus 2 result in severe disruptions to public health. Vaccines and antibody drugs play …

Mechanism-driven design of multispecific antibodies for targeted disease treatment

J Fine, B Meksiriporn, J Tan… - Annual Review of …, 2024 - annualreviews.org
Antibody-based therapeutics constitute a rapidly growing class of pharmaceutical
compounds. However, monoclonal antibodies, which specifically engage only one target …

Pathophysiological effects of autoantibodies in autoimmune encephalitides

M Ryding, AW Mikkelsen, MS Nissen, AC Nilsson… - Cells, 2023 - mdpi.com
The heterogeneity of autoantibody targets in autoimmune encephalitides presents a
challenge for understanding cellular and humoral pathophysiology, and the development of …

Identification of a highly conserved neutralizing epitope within the RBD region of diverse SARS-CoV-2 variants

Y Wang, A Yan, D Song, M Duan, C Dong… - Nature …, 2024 - nature.com
The constant emergence of SARS-CoV-2 variants continues to impair the efficacy of existing
neutralizing antibodies, especially XBB. 1.5 and EG. 5, which showed exceptional immune …

Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation

P Kalailingam, KH Mohd‐Kahliab… - EMBO Molecular …, 2023 - embopress.org
Aging results from the accumulation of molecular damage that impairs normal biochemical
processes. We previously reported that age‐linked damage to amino acid sequence NGR …

IgY antibodies from birds: A review on affinity and avidity

BLB Pacheco, CP Nogueira, EJ Venancio - Animals, 2023 - mdpi.com
Simple Summary IgY antibodies are used in research and in the development of solutions
for immunotherapy and the immunodiagnosis of human and animal diseases. Affinity and …