[HTML][HTML] Adult hippocampal neurogenesis in Alzheimer's disease: A roadmap to clinical relevance
Adult hippocampal neurogenesis (AHN) drops sharply during early stages of Alzheimer's
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …
disease (AD), via unknown mechanisms, and correlates with cognitive status in AD patients …
[HTML][HTML] Neuronal excitation/inhibition imbalance: core element of a translational perspective on Alzheimer pathophysiology
Our incomplete understanding of the link between Alzheimer's Disease pathology and
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …
symptomatology is a crucial obstacle for therapeutic success. Recently, translational studies …
Adult-born dentate granule cells promote hippocampal population sparsity
The dentate gyrus (DG) gates neocortical information flow to the hippocampus. Intriguingly,
the DG also produces adult-born dentate granule cells (abDGCs) throughout the lifespan …
the DG also produces adult-born dentate granule cells (abDGCs) throughout the lifespan …
Single-cell transcriptomics of adult macaque hippocampus reveals neural precursor cell populations
ZZ Hao, JR Wei, D Xiao, R Liu, N Xu, L Tang… - Nature …, 2022 - nature.com
The extent to which neurogenesis occurs in adult primates remains controversial. In this
study, using an optimized single-cell RNA sequencing pipeline, we profiled 207,785 cells …
study, using an optimized single-cell RNA sequencing pipeline, we profiled 207,785 cells …
Mitochondrial pyruvate metabolism regulates the activation of quiescent adult neural stem cells
F Petrelli, V Scandella, S Montessuit, N Zamboni… - Science …, 2023 - science.org
Cellular metabolism is important for adult neural stem/progenitor cell (NSPC) behavior.
However, its role in the transition from quiescence to proliferation is not fully understood. We …
However, its role in the transition from quiescence to proliferation is not fully understood. We …
Laminin-coated electronic scaffolds with vascular topography for tracking and promoting the migration of brain cells after injury
In the adult brain, neural stem cells are largely restricted into spatially discrete neurogenic
niches, and hence areas of neuron loss during neurodegenerative disease or following a …
niches, and hence areas of neuron loss during neurodegenerative disease or following a …
[HTML][HTML] Exerkines and long-term synaptic potentiation: Mechanisms of exercise-induced neuroplasticity
Physical exercise may improve cognitive function by modulating molecular and cellular
mechanisms within the brain. We propose that the facilitation of long-term synaptic …
mechanisms within the brain. We propose that the facilitation of long-term synaptic …
Neural stem cell metabolism revisited: a critical role for mitochondria
Metabolism has emerged as a key regulator of stem cell behavior. Mitochondria are crucial
metabolic organelles that are important for differentiated cells, yet considered less so for …
metabolic organelles that are important for differentiated cells, yet considered less so for …
Chronic in vivo imaging defines age-dependent alterations of neurogenesis in the mouse hippocampus
Neural stem cells (NSCs) generate new neurons throughout life in the mammalian
hippocampus. Advancing age leads to a decline in neurogenesis, which is associated with …
hippocampus. Advancing age leads to a decline in neurogenesis, which is associated with …
Chemotherapy-induced cognitive impairment and hippocampal neurogenesis: a review of physiological mechanisms and interventions
MJ Sekeres, M Bradley-Garcia… - International journal of …, 2021 - mdpi.com
A wide range of cognitive deficits, including memory loss associated with hippocampal
dysfunction, have been widely reported in cancer survivors who received chemotherapy …
dysfunction, have been widely reported in cancer survivors who received chemotherapy …