Cancer is often associated with venous thrombosis, a phenomenon that was first described
by Trousseau in 1865 (Trousseau syndrome). Recent studies have begun to explain how …

Cancers arise and progress genetically amidst profound perturbations of the
microenvironmental and systemic homeostasis. This includes the coagulation system, which …

The origins of modern immunotherapy for cancer can be traced to reports from the late
nineteenth and early twentieth centuries describing tumor regression associated with …

Epidemiological studies conducted during several decades of the last century have
demonstrated the importance of sufficient nutritional supply of selenium (Se) for human …

The linkage between activation of the coagulation system and cancer is well established, as
is deregulation of tissue factor (TF) by cancer cells, their vascular stroma and cancer …

Abstract Proteinase‐activated receptor‐1 (PAR1), a thrombin receptor and the prototype of a
newly discovered G‐protein‐coupled receptor subfamily, plays an important role in tumor …

Genetically altered cancer cells both provoke and respond to changes in their
microenvironment, stroma, and vasculature. This includes local and systemic activation of …

A common feature in the progression of multiple human malignancies is the protracted
deregulation of the coagulation system, often referred to as cancer coagulopathy. Indeed …

Background: Although the pathophysiological mechanisms remain elusive, accumulating
experimental and clinical data are showing that anticoagulants, particularly low molecular …

Interleukin 8 (IL-8) and vascular endothelial growth factor (VEGF) are two cytokines
promoting prostate tumor growth and angiogenesis. The main coagulation protease …