Covering: 2018 to 2022 Antimicrobial resistance (AMR) poses a significant global health
threat. There is a rising demand for innovative drug scaffolds and new targets to combat …

Ethnopharmacological relevance Chronic obstructive pulmonary disease (COPD) is the third
leading cause of death globally and thus imposes heavy economic burden on patients, their …

Botanicals have attracted much attention in the field of anti-inflammatory due to their good
pharmacological activity and efficacy. Andrographis paniculata is a natural plant ingredient …

Natural products (NPs) have consistently played a pivotal role in pharmaceutical research,
exerting profound impacts on the treatment of human diseases. A significant proportion of …

Background Nuclear factor erythroid 2-related factor 2 (Nrf2) is a classical nuclear
transcription factor that regulates the system's anti-oxidative stress response. The activation …

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Frontiers in Pharmacology About us About us Who we are Mission Values History …

The reductionist concept, based on the ligand–receptor interaction, is not a suitable model
for adaptogens, and herbal preparations affect multiple physiological functions, revealing …

The p38 MAPK-MK2 signaling axis functions as an initiator of inflammation. Targeting the
p38 MAPK-MK2 signaling axis represents a direct therapeutic intervention of inflammatory …

Andrographis paniculata is used as a functional food in Asia. Andrographolide (Andro), a
diterpene lactone isolated from Andrographis paniculata, has been reported to have potent …

In spite of the progress in treatment strategies, cancer remains a major cause of death
worldwide. Therefore, the main challenge should be the early diagnosis of cancer and the …