Telomeres in telomerase-negative cells shorten during DNA replication in vitro due to
numerous causes including the inability of DNA polymerases to fully copy the lagging …

Apolipoprotein D (ApoD) is an ancient member of the lipocalin family with a high degree of
sequence conservation from insects to mammals. It is not structurally related to other major …

A brave book with a polemical argument on the paradoxes, struggles and advantages of
aging. How old am I? Don't ask, don't tell. As the baby boomers approach their sixth or …

Although genetic and environmental factors contribute to neurodegenerative disease, the
underlying etiology common to many diseases might be based on metabolic demand …

Oxidative stress plays a major role in the pathogenesis of a variety of acute and chronic
diseases. Measurement of the oxidative stress-related end products may be performed, eg …

Histones are the most abundant proteins associated with genomic DNA. Recent
observations show that histones are quite susceptible to non-enzymatic glycation which …

Telomeres in most human cell types shorten during DNA replication in vitro because of
various factors including the inability of DNA polymerases to fully copy the lagging strand …

Non‐enzymatic glycation and oxidation of self‐proteins, causing formation and
accumulation of advanced glycation end products (AGEs), have been reported in an array of …

Increased bone fragility can stem from age-related and chronic bone affecting diseases
(such as osteoporosis, diabetes and kidney disease), chemotherapeutic and radiation …

Understanding functional differences between mitochondrial subpopulations will help
improve our understanding of mitochondrial disease. Mitochondrial DNA heteroplasmy …