PROTAC'ing oncoproteins: targeted protein degradation for cancer therapy
Molecularly targeted cancer therapies substantially improve patient outcomes, although the
durability of their effectiveness can be limited. Resistance to these therapies is often related …
durability of their effectiveness can be limited. Resistance to these therapies is often related …
IRAK1 and IRAK4 as emerging therapeutic targets in hematologic malignancies
J Bennett, DT Starczynowski - Current Opinion in Hematology, 2022 - journals.lww.com
IRAK-targeted therapies that have matriculated to early phase trials are yielding promising
preliminary results. However, studies of IRAK kinase signaling continue to defy conventional …
preliminary results. However, studies of IRAK kinase signaling continue to defy conventional …
The IRAK4 scaffold integrates TLR4-driven TRIF and MYD88 signaling pathways
Summary Interleukin-1 receptor-associated kinases (IRAKs)− 4,− 2, and− 1 are involved in
transducing signals from Toll-like receptors (TLRs) via the adaptor myeloid differentiation …
transducing signals from Toll-like receptors (TLRs) via the adaptor myeloid differentiation …
MyD88 TIR domain higher-order assembly interactions revealed by microcrystal electron diffraction and serial femtosecond crystallography
MyD88 and MAL are Toll-like receptor (TLR) adaptors that signal to induce pro-inflammatory
cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms …
cytokine production. We previously observed that the TIR domain of MAL (MALTIR) forms …
Molecular definition of the endogenous Toll-like receptor signalling pathways
Innate immune pattern recognition receptors, such as the Toll-like receptors (TLRs), are key
mediators of the immune response to infection and central to our understanding of health …
mediators of the immune response to infection and central to our understanding of health …
Structural and functional understanding of the toll‐like receptors
J Asami, T Shimizu - Protein Science, 2021 - Wiley Online Library
Recognition of invading pathogens by the innate immune system is essential to initiate
antimicrobial responses and trigger adaptive immunity. This is largely mediated by an array …
antimicrobial responses and trigger adaptive immunity. This is largely mediated by an array …
Myeloid differentiation primary response protein 88 (MyD88): the central hub of TLR/IL-1R signaling
L Chen, L Zheng, P Chen, G Liang - Journal of medicinal …, 2020 - ACS Publications
Myeloid differentiation primary response protein 88 (MyD88) is a ubiquitously expressed
cytoplasmic adaptor protein that plays a central role in the Toll-like receptor (TLR) and …
cytoplasmic adaptor protein that plays a central role in the Toll-like receptor (TLR) and …
Regulation of innate immune signaling by IRAK proteins
M Pereira, RT Gazzinelli - Frontiers in Immunology, 2023 - frontiersin.org
The Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1R) families are of paramount
importance in coordinating the early immune response to pathogens. Signaling via most …
importance in coordinating the early immune response to pathogens. Signaling via most …
There's more to death than life: Noncatalytic functions in kinase and pseudokinase signaling
Protein kinases are present in all domains of life and play diverse roles in cellular signaling.
Whereas the impact of substrate phosphorylation by protein kinases has long been …
Whereas the impact of substrate phosphorylation by protein kinases has long been …
Structural evolution of TIR-domain signalosomes
TIR (Toll/interleukin-1 receptor/resistance protein) domains are cytoplasmic domains widely
found in animals and plants, where they are essential components of the innate immune …
found in animals and plants, where they are essential components of the innate immune …