Global impact of proteoglycan science on human diseases

C Xie, L Schaefer, RV Iozzo - Iscience, 2023 - cell.com
In this comprehensive review, we will dissect the impact of research on proteoglycans
focusing on recent developments involved in their synthesis, degradation, and interactions …

Distinct conformations of SARS-CoV-2 Omicron spike protein and its interaction with ACE2 and antibody

M Lee, M Major, H Hong - International Journal of Molecular Sciences, 2023 - mdpi.com
Since November 2021, Omicron has been the dominant severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) variant that causes the coronavirus disease 2019 (COVID-19) …

Antigenic cross-reactivity between SARS-CoV-2 S1-RBD and its receptor ACE2

YC Lai, YW Cheng, CH Chao, YY Chang… - Frontiers in …, 2022 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging virus
responsible for the ongoing COVID-19 pandemic. SARS-CoV-2 binds to the human cell …

Virus-like silica nanoparticles improve permeability of macromolecules across the blood–brain barrier in vitro

Y Feng, Y Cao, Z Qu, TI Janjua, A Popat - Pharmaceutics, 2023 - mdpi.com
The presence of the blood–brain barrier (BBB) limits the delivery of therapies into the brain.
There has been significant interest in overcoming the BBB for the effective delivery of …

The vaccine efficacy against the SARS-CoV-2 omicron: a systemic review and meta-analysis

Y Zou, D Huang, Q Jiang, Y Guo, C Chen - Frontiers in Public Health, 2022 - frontiersin.org
Background COVID-19 is a respiratory illness caused by SARS-CoV-2. The most recent
variant is Omicron (line B. 1.1. 529), which was first identified in South Africa in November …

[HTML][HTML] Suramin inhibits SARS-CoV-2 nucleocapsid phosphoprotein genome packaging function

I Boniardi, A Corona, J Basquin, C Basquin, J Milia… - Virus Research, 2023 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic is fading, however its
etiologic agent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues …

Multi-epitopes vaccine design for surface glycoprotein against SARS-CoV-2 using immunoinformatic approach

SF Arshad, R Rehana, MA Saleem, M Usman… - Heliyon, 2024 - cell.com
Background The recent COVID vaccinations have successfully reduced death and severity
but did not stop the transmission of viruses by the emerging SARS-CoV-2 strain. There is a …

Neutrophil Activity and Extracellular Matrix Degradation: Drivers of Lung Tissue Destruction in Fatal COVID-19 Cases and Implications for Long COVID

T Narasaraju, I Neeli, SL Criswell, A Krishnappa… - Biomolecules, 2024 - mdpi.com
Pulmonary fibrosis, severe alveolitis, and the inability to restore alveolar epithelial
architecture are primary causes of respiratory failure in fatal COVID-19 cases. However, the …

A multicenter study of asymmetric and symmetric dimethylarginine as predictors of mortality risk in hospitalized COVID-19 patients

J Hannemann, A Zink, Y Mileva, P Balfanz, E Dahl… - Scientific Reports, 2024 - nature.com
Mortality of patients hospitalized with COVID-19 has remained high during the consecutive
SARS-CoV-2 pandemic waves. Early discrimination of patients at high mortality risk is …

[HTML][HTML] Coronavirus peplomer interaction

MC Pak, R Chakraborty, MA Kanso… - Physics of …, 2022 - pubs.aip.org
By virtue of their lack of motility, viruses rely entirely on their own temperature (Brownian
motion) to position themselves properly for cell attachment. Spiked viruses use one or more …