Background Age-related cognitive dysfunction, including impairment of hippocampus-
dependent spatial learning and memory, affects approximately half of the aged population …

Neurodegenerative diseases are among the leading causes of disability and death
worldwide. The disease-related socioeconomic burden is expected to increase with the …

Interferon-alpha (IFN-α) is a proinflammatory cytokine that is widely used for the treatment of
chronic viral hepatitis and malignancy, because of its immune-activating, antiviral, and …

Alterations to brain homeostasis during development are reflected in the neurochemical
profile determined noninvasively by 1 H magnetic resonance spectroscopy. We determined …

We previously reported the neuroprotective effects of icariin in rat cortical neurons. Here, we
present a study on icariin's anti-aging effect in 24-month aged mice by treating them with a …

The current trend for the rapid growth of the global aging population poses substantial
challenges for society. The human aging process has been demonstrated to be closely …

Aging is a natural phenomenon characterized by accumulation of cellular damage and
debris. Oxidative stress, cellular senescence, sustained inflammation, and DNA damage are …

Multiple biological processes throughout development require intracellular vesicular
trafficking, where the SNARE (soluble N-ethylmaleimide-sensitive factor (NSF) attachment …

Gut microbiota plays an intrinsic role in communication between the gut and the brain and is
capable of influencing the host brain by producing neurotransmitters and neurotrophins, the …

Context Polygonatum sibiricum polysaccharide (PSP), derived from Polygonatum sibiricum
Delar. ex Redoute (Liliaceae), is known to be able to delay the ageing process. However …