Since the inception of the concept of “magic bullet”, nanoparticles have evolved to be one of
the most effective carriers in drug delivery. Nanoparticles improve the therapeutic efficacy of …

Hitchhiking, a recently developed bio-inspired cargo delivery system, has been harnessed
for diverse applications. By leveraging the interactions between nanoparticles and …

Nanotherapeutics demonstrate poor accumulation in the tumor microenvironment due to
poor extravasation and penetration into the tumor. Therapeutics such as oligonucleotides …

Highlights•The current status of nanomedicines and their clinical translation is summarized.•
Challenges to the clinical translation of nanomedicines are summarized.•Strategies and …

Biopsy is the clinical standard for diagnosing lymph node (LN) metastasis, but it is invasive
and poses significant risk to patient health. Magnetic resonance imaging (MRI) has been …

Macrophages, as highly phenotypic plastic immune cells, play diverse roles in different
pathological conditions. Changing and controlling the phenotypes of macrophages is …

Comprehensive Summary Tumor stroma composing diverse extracellular matrixes (ECM)
and stromal cells shapes a condensed physical barrier, which severely hampers the efficient …

Natural organisms have evolved sophisticated and multiscale hierarchical structures over
time to enable survival. Currently, bionic design is revolutionizing drug delivery systems …

Neutrophils are a crucial component of the innate immune system and play a pivotal role in
various physiological processes. From a physical perspective, hitchhiking is considered a …

The advent of nanotechnology has broadened the scope of technological advances in both
medical and industrial applications. Nanotechnology has paved the way for cancer …