Multi-omics and artificial intelligence-guided drug repositioning: prospects, challenges, and lessons learned from COVID-19

Y Cong, T Endo - OMICS: A Journal of Integrative Biology, 2022 - liebertpub.com
Drug repurposing is of interest for therapeutics innovation in many human diseases
including coronavirus disease 2019 (COVID-19). Methodological innovations in drug …

COVID-19 in rheumatic disease patients on immunosuppressive agents

S Sharmeen, A Elghawy, F Zarlasht, Q Yao - Seminars in Arthritis and …, 2020 - Elsevier
Objective To analyze clinical characteristics and outcome of COVID-19 patients with
underlying rheumatic diseases (RD) on immunosuppressive agents. Method A case series …

Plasticity of glucose metabolism in activated immune cells: advantages for melatonin inhibition of COVID-19 disease

RJ Reiter, R Sharma, Q Ma, C Liu… - Melatonin …, 2020 - melaonin-research.com
COVID-19 has infected hundreds of thousands and killed tens of thousands of people
worldwide and it continues to ravage societies as well as fiscal and economic stability of …

Growth hormone receptor regulation in cancer and chronic diseases

GJ Strous, ADS Almeida, J Putters, J Schantl… - Frontiers in …, 2020 - frontiersin.org
The GHR signaling pathway plays important roles in growth, metabolism, cell cycle control,
immunity, homeostatic processes, and chemoresistance via both the JAK/STAT and the SRC …

Glycyrrhetinic acid: A potential drug for the treatment of COVID-19 cytokine storm

H Li, J You, X Yang, Y Wei, L Zheng, Y Zhao, Y Huang… - Phytomedicine, 2022 - Elsevier
Background The cytokine storm (CS) triggered by coronavirus disease 2019 (COVID-19)
has caused serious harm to health of humanity and huge economic burden to the world, and …

Cyclosporine therapy in cytokine storm due to coronavirus disease 2019 (COVID-19)

E Cure, A Kucuk, M Cumhur Cure - Rheumatology international, 2020 - Springer
There is no absolutely proven treatment for severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) infection. The infection continues to spread rapidly worldwide and causes …

Clinical features and pathogenic mechanisms of gastrointestinal injury in COVID-19

K Mitsuyama, K Tsuruta, H Takedatsu… - Journal of Clinical …, 2020 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the global
coronavirus disease 2019 (COVID-19) outbreak. Along with the respiratory tract, the …

The Role of Inflammatory Cytokines (Interleukin-1 and Interleukin-6) as a Potential Biomarker in the Different Stages of COVID-19 (Mild, Severe, and Critical)

M Ghofrani Nezhad, G Jami, O Kooshkaki… - Journal of Interferon & …, 2023 - liebertpub.com
Cytokine storm refers to the overproduction of immune and inflammatory cells and their
proteins (cytokines)[interleukin (IL)-1 and IL-6] causing acute respiratory distress syndrome …

Silymarin-functionalized selenium nanoparticles prevent LPS-induced inflammatory response in RAW264. 7 cells through downregulation of the PI3K/Akt/NF-κB …

X Mi, HM Le, S Lee, HR Park, YJ Kim - ACS omega, 2022 - ACS Publications
Silymarin exhibits an anti-inflammatory property in various cancers and inflammatory
diseases. In our previous work, silymarin-mediated selenium nanoparticles (SeNPs)(Si …

Early immune responses and prognostic factors in children with COVID-19: a single-center retrospective analysis

W Lu, L Yang, X Li, M Sun, A Zhang, S Qi, Z Chen… - BMC pediatrics, 2021 - Springer
Background Early diagnostic indicators and the identification of possible progression to
severe or critical COVID-19 in children are unknown. To investigate the immune …