Understanding long COVID; mitochondrial health and adaptation—old pathways, new problems

AVW Nunn, GW Guy, W Brysch, JD Bell - Biomedicines, 2022 - mdpi.com
Many people infected with the SARS-CoV-2 suffer long-term symptoms, such as “brain fog”,
fatigue and clotting problems. Explanations for “long COVID” include immune imbalance …

The microbiome: an integral player in immune homeostasis and inflammation in the respiratory tract

O Perdijk, R Azzoni, BJ Marsland - Physiological Reviews, 2024 - journals.physiology.org
The last decade of microbiome research has highlighted its fundamental role in systemic
immune and metabolic homeostasis. The microbiome plays a prominent role during …

Systems-level temporal immune-metabolic profile in Crimean-Congo hemorrhagic fever virus infection

AT Ambikan, N Elaldi… - Proceedings of the …, 2023 - National Acad Sciences
Crimean-Congo hemorrhagic fever (CCHF) caused by CCHF virus (CCHFV) is one of the
epidemic-prone diseases prioritized by the World Health Organisation as public health …

Context-specific genome-scale metabolic modelling and its application to the analysis of COVID-19 metabolic signatures

M Moškon, T Režen - Metabolites, 2023 - mdpi.com
Genome-scale metabolic models (GEMs) have found numerous applications in different
domains, ranging from biotechnology to systems medicine. Herein, we overview the most …

Network-based multi-omics integration reveals metabolic at-risk profile within treated HIV-infection

F Mikaeloff, M Gelpi, R Benfeitas, AD Knudsen… - Elife, 2023 - elifesciences.org
Multiomics technologies improve the biological understanding of health status in people
living with HIV on antiretroviral therapy (PWH). Still, a systematic and in-depth …

Peripheral blood omics and other multiplex-based systems in pulmonary and critical care medicine

J Balnis, EJM Lauria, R Yucel, HA Singer… - American Journal of …, 2023 - atsjournals.org
Over the last years, the use of peripheral blood–derived big datasets in combination with
machine learning technology has accelerated the understanding, prediction, and …

Metabolic and mitochondria alterations induced by SARS‐CoV‐2 accessory proteins ORF3a, ORF9b, ORF9c and ORF10

BD López‐Ayllón, S Marin… - Journal of Medical …, 2024 - Wiley Online Library
Antiviral signaling, immune response and cell metabolism are dysregulated by SARS‐CoV‐
2, the causative agent of COVID‐19. Here, we show that SARS‐CoV‐2 accessory proteins …

Integrated NMR and MS analysis of the plasma metabolome reveals major changes in one-carbon, lipid, and amino acid metabolism in severe and fatal cases of …

MC Gama-Almeida, GDA Pinto, L Teixeira, ED Hottz… - Metabolites, 2023 - mdpi.com
Brazil has the second-highest COVID-19 death rate worldwide, and Rio de Janeiro is among
the states with the highest rate in the country. Although vaccine coverage has been …

Fuzzy optimization for identifying antiviral targets for treating SARS-CoV-2 infection in the heart

SW Chu, FS Wang - BMC bioinformatics, 2023 - Springer
In this paper, a fuzzy hierarchical optimization framework is proposed for identifying potential
antiviral targets for treating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …

Immune Mechanisms Underpinning Long COVID: Collegium Internationale Allergologicum Update 2024

EUC Venterb, PSJ Rohrhofera… - Int Arch Allergy …, 2024 - karger.com
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can
result in a prolonged multisystem disorder termed long COVID, which may affect up to 10 …