H2A. Z is a histone variant that provides specific structural and docking-side properties to the
nucleosome, resulting in diverse and specialised molecular and cellular functions. In this …

The basic unit of chromatin, the nucleosome, is an octamer of four core histone proteins
(H2A, H2B, H3, and H4) and serves as a fundamental regulatory unit in all DNA-templated …

Somatic mutations accumulate in all cells with age and can confer a selective advantage,
leading to clonal expansion over time. In hematopoietic cells, mutations in a subset of genes …

The Plasmodium falciparum alternative histones Pf H2A. Z and Pf H2B. Z are enriched in the
same nucleosomes in intergenic euchromatin but depleted from heterochromatin. They …

In addition to the stage of transcriptional initiation, the production of mRNAs is regulated
during elongation. Accordingly, the synthesis of mRNAs by RNA polymerase II (RNAPII) in …

Poly (ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme involved in processes of cell
cycle regulation, DNA repair, transcription, and replication. Hyperactivity of PARP-1 induced …

The histone variant H2A. Z has been extensively studied to understand its manifold DNA-
based functions. In the past years, researchers identified its specific binding partners, the …

Histone variants are key epigenetic players, but their functional and physiological roles
remain poorly understood. Here, we show that depletion of the histone variant H2A. Z in …

Mammalian circadian oscillators are built on a feedback loop in which the activity of the
transcription factor CLOCK–BMAL1 is repressed by the PER–CRY complex. Here, we show …

Chromatin is the physical substrate of the genome that carries the DNA sequence and
ensures its proper functions and regulation in the cell nucleus. While a lot is known about …