Although previously restricted to a limited number of medical conditions, there is a growing
appreciation that 'autoimmune'(or immune-mediated) processes are important aspects of a …

Animal models that can replicate clinical and pathologic features of severe human
coronavirus infections have been instrumental in the development of novel vaccines and …

Data on the safety and immunity of a heterologous booster (fourth dose) after three-doses of
inactivated SARS-CoV-2 vaccine in Chinese adults are limited. We evaluate the safety and …

Background The contribution of the virus to the pathogenesis of severe COVID-19 is still
unclear. We aimed to evaluate associations between viral RNA load in plasma and host …

Clinical presentations that develop in response to infection result from interactions between
the pathogen and host defenses. SARS-CoV-2, the etiologic agent of COVID-19, directly …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of
COVID-19, has evolved into multiple variants. Animal models are important to understand …

Hypertriglyceridemia, obesity, and aging are among the key risk factors for severe COVID-19
with acute respiratory distress syndrome (ARDS). One of the main prognostic biomarkers of …

Age is associated with reduced efficacy of vaccines and linked to higher risk of severe
COVID-19. Here we determined the impact of ageing on the efficacy of a SARS-CoV-2 …

Blood-brain barrier (BBB) permeability can cause neuroinflammation and cognitive
impairment. Caveolin-1 (Cav-1) critically regulates BBB permeability, but its influence on the …

The study of phenotypic and functional characteristics of immune cells involved in host
response to SARS-CoV-2 is relevant for understanding COVID-19 pathogenesis and …