A comprehensive review on the efficacy of several pharmacologic agents for the treatment of COVID-19

F Haddad, G Dokmak, R Karaman - Life, 2022 - mdpi.com
Simple Summary Treatments for coronavirus disease-2019 (COVID-19) have utilized a
variety of medications, including antivirals, immunomodulators, and other therapeutics such …

[HTML][HTML] Liver injury in COVID-19: Clinical features, potential mechanisms, risk factors and clinical treatments

SW Zhao, YM Li, YL Li, C Su - World Journal of Gastroenterology, 2023 - ncbi.nlm.nih.gov
Abstract The coronavirus disease 2019 (COVID-19) pandemic has been a serious threat to
global health for nearly 3 years. In addition to pulmonary complications, liver injury is not …

The SARS-CoV-2 S1 spike protein promotes MAPK and NF-kB activation in human lung cells and inflammatory cytokine production in human lung and intestinal …

CB Forsyth, L Zhang, A Bhushan, B Swanson, L Zhang… - Microorganisms, 2022 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic began in January 2020 in Wuhan,
China, with a new coronavirus designated SARS-CoV-2. The principal cause of death from …

COVID-19: An Update on the Latest Therapeutic Agents

KY Loo, LTH Tan, JWF Law, KW Hong… - Progress In Microbes …, 2023 - hh-publisher.com
The COVID-19 pandemic has plagued the world for over three years since discovering the
causative virus, SARS-CoV-2, in China. The rampant spread of the virus led to the loss of …

NLRP3, the inflammasome and COVID-19 infection

M Yin, L Marrone, CG Peace… - QJM: An International …, 2023 - academic.oup.com
Abstract Severe coronavirus disease 2019 (COVID-19) is characterized by respiratory
failure, shock or multiorgan dysfunction, often accompanied by systemic hyperinflammation …

[HTML][HTML] Drug repurposing for the treatment of COVID-19: Targeting nafamostat to the lungs by a liposomal delivery system

P Reus, H Guthmann, N Uhlig, M Agbaria… - Journal of Controlled …, 2023 - Elsevier
Despite tremendous global efforts since the beginning of the COVID-19 pandemic, still only
a limited number of prophylactic and therapeutic options are available. Although vaccination …

[HTML][HTML] Immunohematologic Biomarkers in COVID-19: Insights into Pathogenesis, Prognosis, and Prevention

DR Sweet, ML Freeman, DA Zidar - Pathogens and Immunity, 2023 - ncbi.nlm.nih.gov
Abstract Coronavirus disease 2019 (COVID-19) has had profound effects on the health of
individuals and on healthcare systems worldwide. While healthcare workers on the …

Advances in attractive therapeutic approach for macrophage activation syndrome in COVID-19

S Chen, C Zhang, D Chen, L Dong, T Chang… - Frontiers in …, 2023 - frontiersin.org
Nowadays, people have relaxed their vigilance against COVID-19 due to its declining
infection numbers and attenuated virulence. However, COVID-19 still needs to be concern …

Anakinra—An Interleukin-1 Receptor Antagonist for COVID-19

T Nguyen, L Dima, KC Willett - American Journal of Therapeutics, 2023 - journals.lww.com
Background: Coronavirus disease (COVID-19) caused by SARS-CoV-2 virus caused a
global pandemic in 2019. There are limited pharmacologic options available. The Food and …

Beyond an inflammatory mediator: Interleukin‐1 in neurophysiology

TS Lima - Experimental Physiology, 2023 - Wiley Online Library
Since its discovery in the early 1940s, the interleukin‐1 (IL‐1) cytokine family has been
associated primarily with acute and chronic inflammation. The family member IL‐1β is …