Host factors of SARS-CoV-2 in infection, pathogenesis, and long-term effects

Y Zhang, S Chen, Y Tian, X Fu - Frontiers in Cellular and Infection …, 2024 - frontiersin.org
SARS-CoV-2 is the causative virus of the devastating COVID-19 pandemic that results in an
unparalleled global health and economic crisis. Despite unprecedented scientific efforts and …

Role of aryl hydrocarbon receptors in infection and inflammation

L Xu, L Lin, N Xie, W Chen, W Nong, R Li - Frontiers in Immunology, 2024 - frontiersin.org
The aryl hydrocarbon receptor (AhR) is a transcription factor that is activated by various
ligands, including pollutants, microorganisms, and metabolic substances. It is expressed …

Betacoronaviruses SARS-CoV-2 and HCoV-OC43 infections in IGROV-1 cell line require aryl hydrocarbon receptor

M Yousefi, WS Lee, WOY Chan, W He… - Emerging Microbes & …, 2023 - Taylor & Francis
The emergence of novel betacoronaviruses has posed significant financial and human
health burdens, necessitating the development of appropriate tools to combat future …

[HTML][HTML] In vitro evaluation of antiviral activities of funicone-like compounds vermistatin and penisimplicissin against canine coronavirus infection

C Cerracchio, MM Salvatore, L Del Sorbo, F Serra… - Antibiotics, 2023 - mdpi.com
Recent studies have demonstrated that 3-O-methylfunicone (OMF), a fungal secondary
metabolite from Talaromyces pinophilus belonging to the class of funicone-like compounds …

Aryl hydrocarbon receptor activation alters immune cell populations in the lung and bone marrow during coronavirus infection

AM Healey, KN Fenner, CT O'Dell… - American Journal of …, 2024 - journals.physiology.org
Respiratory viral infections are one of the major causes of illness and death worldwide.
Symptoms associated with respiratory infections can range from mild to severe, and there is …

Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes

M Buchynskyi, V Oksenych, I Kamyshna, I Vorobets… - Viruses, 2024 - mdpi.com
Metabolic-associated fatty liver disease (MAFLD) is a risk factor for severe COVID-19. This
study explores the potential influence of gut hormone receptor and immune response gene …

Tryptophan As a New Member of RNA‐Induced Silencing Complexes Prevents Colon Cancer Liver Metastasis

F Xu, Y Ren, Y Teng, J Mu, J Tang… - Advanced …, 2024 - Wiley Online Library
Essential amino acids (EAA) and microRNAs (miRs) control biological activity of a cell.
Whether EAA regulates the activity of miR has never been demonstrated. Here, as proof‐of …

[HTML][HTML] Fungal metabolite 6-pentyl-α-pyrone reduces canine coronavirus infection

C Cerracchio, L Del Sorbo, F Serra, A Staropoli… - Heliyon, 2024 - cell.com
Canine coronavirus (CCoV) can produce a self-limited enteric disease in dogs but, because
of notable biological plasticity of coronaviruses (CoVs), numerous mutations as well as …

[HTML][HTML] Activation of Chaperone-Mediated Autophagy Inhibits the Aryl Hydrocarbon Receptor Function by Degrading This Receptor in Human Lung Epithelial …

R Xiong, D Shao, S Do, WK Chan - International Journal of Molecular …, 2023 - mdpi.com
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor and a
substrate protein of a Cullin 4B E3 ligase complex responsible for diverse cellular …

Primate-specific BTN3A2 protects against SARS-CoV-2 infection by interacting with and reducing ACE2

L Xu, D Yu, M Xu, LX Yang, QC Zou, XL Feng, MH Li… - bioRxiv, 2024 - biorxiv.org
Coronavirus disease 2019 (COVID-19) is an immune-related disorder caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). SARS-CoV-2 invades cells via the …