Diagnosis and management of patients with the α-gal syndrome

TAE Platts-Mills, R Li, B Keshavarz, AR Smith… - The Journal of Allergy …, 2020 - Elsevier
The galactose-α-1, 3-galactose (α-Gal) syndrome has many novel features that are relevant
to diagnosis and management. In most cases, the diagnosis can be made on a history of …

Tick saliva and the alpha-gal syndrome: finding a needle in a haystack

SR Sharma, S Karim - Frontiers in cellular and infection microbiology, 2021 - frontiersin.org
Ticks and tick-borne diseases are significant public health concerns. Bioactive molecules in
tick saliva facilitate prolonged blood-feeding and transmission of tick-borne pathogens to the …

Discovery of alpha-gal-containing antigens in North American tick species believed to induce red meat allergy

G Crispell, SP Commins, SA Archer-Hartman… - Frontiers in …, 2019 - frontiersin.org
Development of specific IgE antibodies to the oligosaccharide galactose-α-1, 3-galactose (α-
gal) following tick bites has been shown to be the source of red meat allergy. In this study …

Anti-Tick Microbiota Vaccine Impacts Ixodes ricinus Performance during Feeding

L Mateos-Hernández, D Obregón, J Maye, J Borneres… - Vaccines, 2020 - mdpi.com
The tick microbiota is a highly complex ensemble of interacting microorganisms. Keystone
taxa, with a central role in the microbial networks, support the stability and fitness of the …

Environmental and molecular drivers of the α-Gal syndrome

A Cabezas-Cruz, A Hodžić… - Frontiers in …, 2019 - frontiersin.org
The α-Gal syndrome (AGS) is a type of allergy characterized by an IgE antibody (Ab)
response against the carbohydrate Galα1-3Galβ1-4GlcNAc-R (α-Gal), which is present in …

The α-Gal syndrome and potential mechanisms

P Román-Carrasco, W Hemmer, A Cabezas-Cruz… - Frontiers in …, 2021 - frontiersin.org
The α-Gal syndrome is a complex allergic disease characterized by the development of
specific IgE antibodies against the carbohydrate galactose-α-1, 3-galactose (α-Gal), an …

On the cause and consequences of IgE to galactose-α-1, 3-galactose: A report from the National Institute of Allergy and Infectious Diseases Workshop on …

TAE Platts-Mills, SP Commins, T Biedermann… - Journal of Allergy and …, 2020 - Elsevier
The mammalian meat allergy known as the “α-Gal syndrome” relates to IgE specific for
galactose-α-1, 3-galactose (α-Gal), an oligosaccharide that is present in cells and tissues of …

TickSialoFam (TSFam): a database that helps to classify tick salivary proteins, a review on tick salivary protein function and evolution, with considerations on the tick …

JMC Ribeiro, BJ Mans - Frontiers in cellular and infection microbiology, 2020 - frontiersin.org
Tick saliva contains a complex mixture of peptides and non-peptides that counteract their
hosts' hemostasis, immunity, and tissue-repair reactions. Recent transcriptomic studies have …

Red meat allergy in children and adults

JM Wilson, TAE Platts-Mills - Current opinion in allergy and …, 2019 - journals.lww.com
Red meat allergy in children and adults : Current Opinion in Allergy and Clinical Immunology
Red meat allergy in children and adults : Current Opinion in Allergy and Clinical Immunology …

Galactose α-1, 3-galactose phenotypes: lessons from various patient populations

M Levin, D Apostolovic, T Biedermann… - Annals of Allergy …, 2019 - Elsevier
Objective To review published studies on galactose α-1, 3-galactose (α-gal), a carbohydrate
epitope found on proteins and lipids in nonprimate mammals and present in foods …