Members of the human epidermal growth factor receptor (HER) family, which includes HER1
(also known as EGFR), HER2, HER3 and HER4, have played a central role in regulating cell …

The epidermal growth factor receptor (EGFR) belongs to the tyrosine kinase receptors family
and is present in the epithelial cell membrane. Its endogenous activation occurs through the …

Background Approximately 50% of newly diagnosed glioblastomas (GBMs) harbor
epidermal growth factor receptor gene amplification (EGFR-amp). Preclinical and early …

Traditional cancer chemotherapy easily produces serious toxic and side effects due to the
lack of specific selection of tumor cells, which restricts its curative effect. Targeted delivery …

The over expression of EGFR has been recognized as the driver mechanism in the
occurrence and progression of carcinomas such as lung cancer, breast cancer, pancreatic …

Monoclonal antibodies (mAbs) and antibody–drug conjugates (ADCs) are two of the most
important therapeutic drug classes that require extensive characterization, whereas their …

The epidermal growth factor receptor (EGFR) is vital for many different types of cancer.
Nimotuzumab (NmAb), an anti-EGFR monoclonal antibody (mAb), is used against some of …

Epidermal growth factor receptor (EGFR) is an integral surface protein mediating cellular
response to a number of growth factors. Its overexpression and increased activation due to …

In 1971, Folkman proposed that tumors could be limited to very small sizes by blocking
angiogenesis. Angiogenesis is the generation of new blood vessels from pre-existing …

Simple Summary Non-small-cell lung cancer (NSCLC) accounts for approximately 85% of
all lung cancers, and the postoperative survival of early-stage NSCLC patients remains …