Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium

M Packer - Journal of the American College of Cardiology, 2018 - jacc.org
Epicardial adipose tissue has unique properties that distinguish it from other depots of
visceral fat. Rather than having distinct boundaries, the epicardium shares an unobstructed …

Characterization of the inflammatory‐metabolic phenotype of heart failure with a preserved ejection fraction: a hypothesis to explain influence of sex on the evolution …

M Packer, CSP Lam, LH Lund… - European Journal of …, 2020 - Wiley Online Library
Accumulating evidence points to the existence of an inflammatory‐metabolic phenotype of
heart failure with a preserved ejection fraction (HFpEF), which is characterized by …

Leptin-aldosterone-neprilysin axis: identification of its distinctive role in the pathogenesis of the three phenotypes of heart failure in people with obesity

M Packer - Circulation, 2018 - Am Heart Assoc
Obesity (especially visceral adiposity) can be associated with 3 different phenotypes of heart
failure: heart failure with a reduced ejection fraction, heart failure with a preserved ejection …

Derangements in adrenergic–adipokine signalling establish a neurohormonal basis for obesity‐related heart failure with a preserved ejection fraction

M Packer - European journal of heart failure, 2018 - Wiley Online Library
Among patients with heart failure and a preserved ejection (HFpEF), obesity is associated
with a distinct phenotype that is characterized by adiposity‐driven plasma volume expansion …

[HTML][HTML] Association between epicardial adipose tissue and incident heart failure mediating by alteration of natriuretic peptide and myocardial strain

M Choy, Y Huang, Y Peng, W Liang, X He, C Chen, J Li… - BMC medicine, 2023 - Springer
Background Epicardial adipose tissue (EAT) has been suggested to exert deleterious effects
on myocardium and cardiovascular disease (CVD) consequence. We evaluated the …

Pharmacogenomics of the natriuretic peptide system in heart failure

A Abuzaanona, D Lanfear - Current heart failure reports, 2017 - Springer
Abstract Purpose of Review Heart failure (HF) continues to be a public health burden
despite advances in therapy, and the natriuretic peptide (NP) system is clearly of critical …

[HTML][HTML] Manifold implications of obesity in ischemic heart disease among Japanese patients according to covariance structure analysis: Low reactivity of B-type …

J Tsutsumi, K Minai, M Kawai, K Ogawa, Y Inoue… - PLoS …, 2017 - journals.plos.org
Background/Objectives Obesity is believed to be one of the major risk factors for
cardiovascular disease in Western countries. However, the effects of obesity should be …

Utility of natriuretic peptides to assess and manage patients with heart failure receiving angiotensin receptor blocker/neprilysin inhibitor therapy

AS Maisel, LB Daniels, IS Anand… - Postgraduate …, 2018 - Taylor & Francis
Levels of natriuretic peptides (NPs), such as B-type NP (BNP) and the N-terminal fragment of
its prohormone (NT-proBNP), are well-established biomarkers for patients with heart failure …

Pharmacology of cardio-oncology: Chronotropic and lusitropic effects of B-type natriuretic peptide in cancer patients with early diastolic dysfunction induced by …

P Menna, V Calabrese, G Armento, O Annibali… - … of Pharmacology and …, 2018 - ASPET
B-type natriuretic peptide (BNP) is widely used as a diagnostic marker of systolic
dysfunction. We previously conducted a clinical study in which anthracycline or …

Obesity-associated heart failure as a theoretical target for treatment with mineralocorticoid receptor antagonists

M Packer - JAMA cardiology, 2018 - jamanetwork.com
Importance Despite their clinical benefits, mineralocorticoid receptor antagonists are greatly
underprescribed by most practitioners who treat patients with chronic heart failure. A novel …