The heterogeneity of tissue macrophages, in health and in disease, has become
increasingly transparent over the last decade. But with the plethora of data comes a natural …

Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

Abstract Characterization of the genetic landscape of Alzheimer's disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Most genetic variants identified from genome-wide association studies (GWAS) in humans
are noncoding, indicating their role in gene regulation. Previous studies have shown …

Biobanks facilitate genome-wide association studies (GWASs), which have mapped
genomic loci across a range of human diseases and traits. However, most biobanks are …

Loss-of-function variants of TREM2 are associated with increased risk of Alzheimer's
disease (AD), suggesting that activation of this innate immune receptor may be a useful …

The APOE4 allele is the strongest genetic risk factor for late-onset Alzheimer's disease (AD).
The contribution of microglial APOE4 to AD pathogenesis is unknown, although APOE has …

Alzheimer's disease (AD) is the most common cause of dementia worldwide, and its
prevalence is rapidly increasing due to extended lifespans. Among the increasing number of …

The concept of immune privilege suggests that the central nervous system is isolated from
the immune system. However, recent studies have highlighted the borders of the central …

Consistent with the concept of the gut-brain phenomenon, observational studies suggest a
relationship between Alzheimer's disease (AD) and gastrointestinal tract (GIT) disorders; …