Epigenetic dysregulation emerges as a critical hallmark and driving force of aging. Although
still an evolving field with much to explore, it has rapidly gained significance by providing …

Chronological age is the most important risk factor for the incidence of age-related diseases.
The pace of ageing determines the magnitude of that risk and can be expressed as …

Cardiovascular health (CVH) is a well-known predictor of morbidity and mortality, while
phenotypic age (PhenoAge) is a promising biomarker of aging. This study aimed to explore …

DNA methylation‐based age estimators (DNAm ageing clocks) are currently one of the most
promising biomarkers for predicting biological age. However, the relationships between …

Lipid signaling is involved in longevity regulation, but which specific lipid molecular species
affect human biological aging remains largely unknown. We investigated the relation …

Physical activity is consistently associated with better health and longer life spans. However,
the extent to which length and intensity of exercise across the life course impact health …

DNA methylation (DNAm) clocks hold promise for measuring biological age, useful for
guiding clinical interventions and forensic identification. This study compared the commonly …

Moderate physical training has been shown to hinder age‐related memory decline. While
the benefits of physical training on hippocampal memory function are well‐documented, little …

Chronic, low-grade inflammation increases with aging, contributing to functional declines
and diseases that reduce healthspan. Growing evidence suggests that transcripts from …

Multiple epigenetic factors play a regulatory role in maintaining the homeostasis of
cutaneous components and are implicated in the aging process of the skin. They have been …