Natural killer cells as allogeneic effectors in adoptive cancer immunotherapy

KB Lupo, S Matosevic - Cancers, 2019 - mdpi.com
Natural killer (NK) cells are attractive within adoptive transfer settings in cancer
immunotherapy due to their potential for allogeneic use; their alloreactivity is enhanced …

NK cell receptor imbalance and NK cell dysfunction in HBV infection and hepatocellular carcinoma

C Sun, H Sun, C Zhang, Z Tian - Cellular & molecular immunology, 2015 - nature.com
Hepatocellular carcinoma (HCC) is currently the third leading cause of cancer mortality and
a common poor-prognosis malignancy due to postoperative recurrence and metastasis …

Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity against ovarian cancers

D Bordoloi, AJ Kulkarni, OS Adeniji, MB Pampena… - Science …, 2023 - science.org
Ovarian cancer (OC) is a lethal gynecologic malignancy, with modest responses to CPI.
Engagement of additional immune arms, such as NK cells, may be of value. We focused on …

Clinical utility of natural killer cells in cancer therapy and transplantation

DA Knorr, V Bachanova, MR Verneris, JS Miller - Seminars in immunology, 2014 - Elsevier
Natural killer (NK) cells recognize deranged cells that display stress receptors or loss of
major histocompatibility complex (MHC) class I. During development, NK cells become …

Cell surface sphingomyelin: Key role in cancer initiation, progression, and immune evasion

H Tallima, HME Azzazy, R El Ridi - Lipids in Health and Disease, 2021 - Springer
Cell surface biochemical changes, notably excessive increase in outer leaflet sphingomyelin
(SM) content, are important in cancer initiation, growth, and immune evasion. Innumerable …

Advances in clinical NK cell studies: donor selection, manufacturing and quality control

U Koehl, C Kalberer, J Spanholtz, DA Lee… - …, 2016 - Taylor & Francis
Natural killer (NK) cells are increasingly used in clinical studies in order to treat patients with
various malignancies. The following review summarizes platform lectures and 2013–2015 …

The clinical significance and role of CXCL1 chemokine in gastrointestinal cancers

J Korbecki, M Bosiacki, K Barczak, R Łagocka… - Cells, 2023 - mdpi.com
One area of cancer research is the interaction between cancer cells and immune cells, in
which chemokines play a vital role. Despite this, a comprehensive summary of the …

The multifaceted role of STAT3 in NK-cell tumor surveillance

A Witalisz-Siepracka, K Klein, B Zdársky… - Frontiers in …, 2022 - frontiersin.org
Signal transducer and activator of transcription 3 (STAT3) is a member of the Janus kinase
(JAK)-STAT pathway, which is one of the key pathways contributing to cancer. STAT3 …

Efficient generation of gene-modified human natural killer cells via alpharetroviral vectors

JD Suerth, MA Morgan, S Kloess, D Heckl… - Journal of molecular …, 2016 - Springer
Natural killer (NK) cells play an important role in tumor immunotherapy with their unique
capability of killing transformed cells without the need for prior sensitization and without …

Role of immune system in tumor progression and carcinogenesis

S Upadhyay, N Sharma, KB Gupta… - Journal of cellular …, 2018 - Wiley Online Library
Tumor micro‐environment has potential to customize the behavior of the immune cell
according to their need. In immune‐eliminating phase, immune cells eliminate transformed …