Oral anticoagulants are a mainstay of cardiovascular therapy, and for over 60 years vitamin
K antagonists (VKAs) were the only available agents for long-term use. VKAs interfere with …

Until recently, vitamin K antagonists were the only available oral anticoagulants, but with
numerous limitations that prompted the introduction of new oral anticoagulants targeting the …

Introduction: Atrial fibrillation (AF) is increasing in prevalence and is associated with
significant morbidity and mortality. The optimal diagnostic and treatment strategies for AF are …

Thus, the task of writing Guidelines or Expert Consensus Documents covers not only the
integration of the most recent research, but also the creation of educational tools and …

Guidelines for pre-operative cardiac risk assessment and per... : European Journal of
Anaesthesiology | EJA Guidelines for pre-operative cardiac risk assessment and perioperative …

Coagulation involves the regulated sequence of proteolytic activation of a series of
zymogens to achieve appropriate and timely haemostasis in an injured vessel, in an …

Contrary to previous models based on plasma, coagulation processes are currently believed
to be mostly cell surface-based, including three overlapping phases: initiation, when tissue …

The serine protease thrombin, a naturally derived enzyme, plays a key role in hemostasis by
converting fibrinogen to fibrin and activating coagulation factor XIII whereby the fibrin clot is …

Prediction models are the key to individualized drug therapy. Warfarin is a typical example of
where pharmacogenetics could help the individual patient by modeling the dose, based on …

Designing efficient fluorescent probes with Aggregation Induced Emission (AIE) feature,
especially for sensing biologically important analytes, is an intensive area of investigation …