Pregnant women with covid-19 are at greater risk of severe disease than their non-pregnant
peers, and yet they are frequently denied investigations or treatments because of unfounded …

COVID‐19 is a complex disease manifesting in a broad severity spectrum and involving
distinct organs and systems. Hyperinflammation, including complement over‐activation, has …

Elevated concentrations of interleukin-6 have been demonstrated to be an important key
factor in COVID-19 host immune impairment. It represents an important prognostic factor of …

Advances in understanding the physiologic functions of the tumor necrosis factor
superfamily (TNFSF) of ligands, receptors, and signaling networks are providing deeper …

According to the Geroscience concept that organismal aging and age-associated diseases
share the same basic molecular mechanisms, the identification of biomarkers of age that can …

Data suggest that interleukin (IL)-6 blockade could reduce mortality in severe COVID-19, yet
IL-6 is only modestly elevated in most patients. Chen et al. describe the role of soluble …

Background Monoclonal antibodies (mAbs) are laboratory‐produced molecules derived
from the B cells of an infected host. They are being investigated as potential prophylaxis to …

Shortness of breath, chest pain, and palpitations occur as postacute sequelae of COVID-19,
but whether symptoms are associated with echocardiographic abnormalities, cardiac …

Background Hyperinflammation with dysregulated production of galectins and cytokines
may develop in COVID-19 or adult-onset Still's disease (AOSD). Given the similar clinical …

Importance Hospitalized patients with COVID-19 pneumonia have high rates of morbidity
and mortality. Objective To assess the efficacy of colchicine in hospitalized patients with …