The use of tocilizumab in patients with COVID-19: a systematic review, meta-analysis and trial sequential analysis of randomized controlled studies

AE Maraolo, A Crispo, M Piezzo, P Di Gennaro… - Journal of clinical …, 2021 - mdpi.com
Background: Among the several therapeutic options assessed for the treatment of
coronavirus disease 2019 (COVID-19), tocilizumab (TCZ), an antagonist of the interleukine …

Comprehensive antibody and cytokine profiling in hospitalized COVID-19 patients in relation to clinical outcomes in a large Belgian cohort

P Ruytinx, P Vandormael, J Fraussen, Z Pieters… - Scientific Reports, 2023 - nature.com
The immune response in patients with Coronavirus Disease 2019 (COVID-19) is highly
variable and is linked to disease severity and mortality. However, antibody and cytokine …

Efficacy and safety of tocilizumab versus standard care/placebo in patients with COVID‐19; a systematic review and meta‐analysis of randomized clinical trials

D Vela, Z Vela‐Gaxha, M Rexhepi… - British Journal of …, 2022 - Wiley Online Library
Aims Tocilizumab has emerged as an important therapy in treating patients with coronavirus
disease (COVID‐19). Our purpose was to evaluate the efficacy and safety of tocilizumab …

The immunology of SARS-CoV-2 infection and vaccines in solid organ transplant recipients

D Dęborska-Materkowska, D Kamińska - Viruses, 2021 - mdpi.com
Since its outbreak in December 2019, the coronavirus disease 2019 (COVID-19) pandemic,
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), led to an …

Influence of extracorporeal cytokine adsorption on hemodynamics in severe acute pancreatitis: results of the matched cohort pancreatitis cytosorbents inflammatory …

S Rasch, S Sancak, J Erber, J Wießner… - Artificial …, 2022 - Wiley Online Library
Background Outcome of severe acute pancreatitis (SAP) highly depends on the degree of
systemic inflammation and organ failure. Although treatment approaches targeting the …

[PDF][PDF] Evaluation of financial conflicts of interest and drug statements in the coronavirus disease 2019 clinical practice guideline in Japan

T Hashimoto, A Murayama, H Mamada, H Saito… - Clinical Microbiology …, 2022 - Elsevier
Since the coronavirus disease 2019 (COVID-19) outbreak in late 2019, evidence on its
treatment has accumulated rapidly. Accordingly, many countries subsequently drafted …

How to update a living systematic review and keep it alive during a pandemic: a practical guide

L Heron, D Buitrago-Garcia, AM Ipekci, R Baumann… - Systematic …, 2023 - Springer
Background The covid-19 pandemic has highlighted the role of living systematic reviews.
The speed of evidence generated during the covid-19 pandemic accentuated the …

The janus-kinase inhibitor ruxolitinib in SARS-CoV-2 induced acute respiratory distress syndrome (ARDS)

A Neubauer, J Johow, E Mack, A Burchert, D Meyn… - Leukemia, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes COVID-19
(coronavirus disease 2019), which is associated with high morbidity and mortality, especially …

[HTML][HTML] A meta-summary and bioinformatic analysis identified interleukin 6 as a master regulator of COVID-19 severity biomarkers

M Ghanem, SJ Brown, AEAT Mohamed, HR Fuller - Cytokine, 2022 - Elsevier
With the rising demand for improved COVID-19 disease monitoring and prognostic markers,
studies have aimed to identify biomarkers using a range of screening methods. However …

High-CBD cannabis extracts inhibit the expression of proinflammatory factors via miRNA-mediated silencing in human small intestinal epithelial cells

B Wang, D Li, A Fiselier, I Kovalchuk, O Kovalchuk - Heliyon, 2023 - cell.com
The incidence of chronic inflammatory disorders and autoimmune diseases is rapidly
growing. To date, the COVID-19 pandemic caused by SARS-CoV-2 has killed over …