Tumours comprise a heterogeneous collection of cells with distinct genetic and phenotypic
properties that can differentially promote progression, metastasis and drug resistance …

An ongoing technological revolution is continually improving our ability to carry out very high-
resolution studies of gene expression patterns. Current technology enables the global gene …

Diverse subtypes of renal cell carcinomas (RCCs) display a wide spectrum of
histomorphologies, proteogenomic alterations, immune cell infiltration patterns, and clinical …

Although we can increasingly measure transcription, chromatin, methylation, and other
aspects of molecular biology at single-cell resolution, most assays survey only one aspect of …

Our understanding of kidney disease pathogenesis is limited by an incomplete molecular
characterization of the cell types responsible for the organ's multiple homeostatic functions …

Kidney organoids derived from human pluripotent stem cells have great utility for
investigating organogenesis and disease mechanisms and, potentially, as a replacement …

Chronic kidney disease affects 10% of the population with notable differences in ethnic and
sex-related susceptibility to kidney injury and disease. Kidney dysfunction leads to …

Background The repertoire of protein expression along the renal tubule depends both on
regulation of transcription and regulation of alternative splicing that can generate multiple …

Kidney stone disease causes significant morbidity and increases health care utilization. In
this work, we decipher the cellular and molecular niche of the human renal papilla in …

Defining cellular and molecular identities within the kidney is necessary to understand its
organization and function in health and disease. Here we demonstrate a reproducible …