Alzheimer disease (AD) is the most common contributor to dementia in the world, but
strategies that slow or prevent its clinical progression have largely remained elusive, until …

Brain macrophages include microglia in the parenchyma, border-associated macrophages
in the meningeal-choroid plexus-perivascular space, and monocyte-derived macrophages …

Neuronal hyperactivity is a key feature of early stages of Alzheimer's disease (AD). Genetic
studies in AD support that microglia act as potential cellular drivers of disease risk, but the …

Microglia are resident macrophages of the central nervous system that have key functions in
its development, homeostasis and response to damage and infection. Although microglia …

Alzheimer disease (AD) is the most common neurodegenerative disease, and with no
efficient curative treatment available, its medical, social, and economic burdens are …

Summary Microglia (MG), the brain-resident macrophages, play major roles in health and
disease via a diversity of cellular states. While embryonic MG display a large heterogeneity …

Microglial reactivity to injury and disease is emerging as a heterogeneous, dynamic, and
crucial determinant in neurological disorders. However, the plasticity and fate of disease …

Alzheimer's disease (AD) is an aging-related form of dementia associated with the
accumulation of pathological aggregates of amyloid beta and neurofibrillary tangles in the …

Lipoproteins in cerebrospinal fluid (CSF) of the central nervous system (CNS) resemble
plasma high-density lipoproteins (HDLs), which are a compositionally and structurally …

Brain perivascular macrophages are specialized populations of macrophages that reside in
the space around cerebral vessels, such as penetrating arteries and venules. With the help …