Immunological mechanisms of vaccine-induced protection against COVID-19 in humans

M Sadarangani, A Marchant… - Nature Reviews …, 2021 - nature.com
Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing
antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including …

Immunological considerations for COVID-19 vaccine strategies

M Jeyanathan, S Afkhami, F Smaill, MS Miller… - Nature Reviews …, 2020 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) is the most formidable challenge to …

Insights into the recent 2019 novel coronavirus (SARS-CoV-2) in light of past human coronavirus outbreaks

HM Ashour, WF Elkhatib, MM Rahman, HA Elshabrawy - Pathogens, 2020 - mdpi.com
Coronaviruses (CoVs) are RNA viruses that have become a major public health concern
since the Severe Acute Respiratory Syndrome-CoV (SARS-CoV) outbreak in 2002. The …

COVID-19 pandemic: Insights into structure, function, and hACE2 receptor recognition by SARS-CoV-2

A Mittal, K Manjunath, RK Ranjan, S Kaushik… - PLoS …, 2020 - journals.plos.org
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a newly emerging,
highly transmissible, and pathogenic coronavirus in humans that has caused global public …

CoV-AbDab: the coronavirus antibody database

MIJ Raybould, A Kovaltsuk, C Marks… - Bioinformatics, 2021 - academic.oup.com
Motivation The emergence of a novel strain of betacoronavirus, SARS-CoV-2, has led to a
pandemic that has been associated with over 700 000 deaths as of August 5, 2020 …

From SARS to MERS, thrusting coronaviruses into the spotlight

Z Song, Y Xu, L Bao, L Zhang, P Yu, Y Qu, H Zhu… - viruses, 2019 - mdpi.com
Coronaviruses (CoVs) have formerly been regarded as relatively harmless respiratory
pathogens to humans. However, two outbreaks of severe respiratory tract infection, caused …

[PDF][PDF] Human B cell clonal expansion and convergent antibody responses to SARS-CoV-2

SCA Nielsen, F Yang, KJL Jackson, RA Hoh… - Cell host & …, 2020 - cell.com
B cells are critical for the production of antibodies and protective immunity to viruses. Here
we show that patients infected with severe acute respiratory syndrome coronavirus 2 (SARS …

Inhibitors of SARS-CoV-2 entry: current and future opportunities

S Xiu, A Dick, H Ju, S Mirzaie, F Abdi… - Journal of medicinal …, 2020 - ACS Publications
Recently, a novel coronavirus initially designated 2019-nCoV but now termed SARS-CoV-2
has emerged and raised global concerns due to its virulence. SARS-CoV-2 is the etiological …

[HTML][HTML] Perspectives on therapeutic neutralizing antibodies against the Novel Coronavirus SARS-CoV-2

G Zhou, Q Zhao - International Journal of Biological Sciences, 2020 - ncbi.nlm.nih.gov
A newly identified novel coronavirus (SARS-CoV-2) is causing pneumonia-associated
respiratory syndrome across the world. Epidemiology, genomics, and pathogenesis of the …

[HTML][HTML] Monoclonal antibody as a potential anti-COVID-19

L Jahanshahlu, N Rezaei - Biomedicine & Pharmacotherapy, 2020 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) is expanding rapidly, which made it as one
of top priorities for scientists to develop novel treatment strategies. Researchers are racing to …