[HTML][HTML] A guide to immunotherapy for COVID-19

FL van de Veerdonk, E Giamarellos-Bourboulis… - Nature medicine, 2022 - nature.com
Immune dysregulation is an important component of the pathophysiology of COVID-19. A
large body of literature has reported the effect of immune-based therapies in patients with …

The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity

MF Osuchowski, MS Winkler, T Skirecki… - The Lancet …, 2021 - thelancet.com
The zoonotic SARS-CoV-2 virus that causes COVID-19 continues to spread worldwide, with
devastating consequences. While the medical community has gained insight into the …

Innate immunological pathways in COVID-19 pathogenesis

SR Paludan, TH Mogensen - Science immunology, 2022 - science.org
Coronavirus disease 2019 (COVID-19) is a disease characterized by a profound
dysregulation of the innate immune system. This knowledge has emerged from the large …

[HTML][HTML] Monocytes and Macrophages in COVID-19

R Knoll, JL Schultze, J Schulte-Schrepping - Frontiers in immunology, 2021 - frontiersin.org
COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing
pandemic with massive global health and socioeconomic consequences. The disease is …

[HTML][HTML] T cell response to SARS-CoV-2 infection in humans: A systematic review

M Shrotri, MCI van Schalkwyk, N Post, D Eddy… - PloS one, 2021 - journals.plos.org
Background Understanding the T cell response to SARS-CoV-2 is critical to vaccine
development, epidemiological surveillance and disease control strategies. This systematic …

[HTML][HTML] Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

AK Maher, KL Burnham, EM Jones, MMH Tan… - Nature …, 2022 - nature.com
Although alterations in myeloid cells have been observed in COVID-19, the specific
underlying mechanisms are not completely understood. Here, we examine the function of …

[HTML][HTML] Severe COVID-19 is characterized by the co-occurrence of moderate cytokine inflammation and severe monocyte dysregulation

B Bonnet, J Cosme, C Dupuis, E Coupez, M Adda… - …, 2021 - thelancet.com
Background SARS-CoV-2 has been responsible for considerable mortality worldwide, owing
in particular to pulmonary failures such as ARDS, but also to other visceral failures and …

[HTML][HTML] Neutrophils and COVID-19: active participants and rational therapeutic targets

J Hazeldine, JM Lord - Frontiers in immunology, 2021 - frontiersin.org
Whilst the majority of individuals infected with severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19, experience mild to …

Increased incidence of ventilator-acquired pneumonia in coronavirus disease 2019 patients: a multicentric cohort study

CH Vacheron, A Lepape, A Savey, A Machut… - Critical care …, 2022 - journals.lww.com
OBJECTIVES: Little is known about the epidemiology of ventilator-acquired pneumonia
among coronavirus disease 2019 patients such as incidence or etiological agents. Some …

[HTML][HTML] Increased LPS levels coexist with systemic inflammation and result in monocyte activation in severe COVID-19 patients

PC Teixeira, GP Dorneles, PC Santana Filho… - International …, 2021 - Elsevier
Mucosal barrier alterations may play a role in the pathogenesis of several diseases,
including COVID-19. In this study we evaluate the association between bacterial …