Astrocytes in human central nervous system diseases: a frontier for new therapies

A Verkhratsky, A Butt, B Li, P Illes, R Zorec… - … and Targeted Therapy, 2023 - nature.com
Astroglia are a broad class of neural parenchymal cells primarily dedicated to homoeostasis
and defence of the central nervous system (CNS). Astroglia contribute to the …

Understanding acquired brain injury: a review

L Goldman, EM Siddiqui, A Khan, S Jahan… - Biomedicines, 2022 - mdpi.com
Any type of brain injury that transpires post-birth is referred to as Acquired Brain Injury (ABI).
In general, ABI does not result from congenital disorders, degenerative diseases, or by brain …

Neuroinflammation following traumatic brain injury: take it seriously or not

R Zheng, K Lee, Z Qi, Z Wang, Z Xu, X Wu… - Frontiers in …, 2022 - frontiersin.org
Traumatic brain injury (TBI) is associated with high mortality and disability, with a substantial
socioeconomic burden. With the standardization of the treatment process, there is increasing …

N-Acetyl-Aspartyl-Glutamate in Brain Health and Disease

C Morland, K Nordengen - International Journal of Molecular Sciences, 2022 - mdpi.com
N-acetyl-aspartyl-glutamate (NAAG) is the most abundant dipeptide in the brain, where it
acts as a neuromodulator of glutamatergic synapses by activating presynaptic metabotropic …

Cellular and molecular pathophysiology of traumatic brain injury: what have we learned so far?

MAM Freire, GS Rocha, LO Bittencourt, D Falcao… - Biology, 2023 - mdpi.com
Simple Summary Traumatic brain injury (TBI) is a catastrophic event to the health and life of
its sufferers, and it also affects their relatives. In addition to the underlying complications of …

Immune modulation after traumatic brain injury

M Bouras, K Asehnoune, A Roquilly - Frontiers in Medicine, 2022 - frontiersin.org
Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue,
followed by a systematization of the inflammatory response. The subsequent response …

[HTML][HTML] Inflammation and immunomodulation in central nervous system injury–B cells as a novel therapeutic opportunity

S Maheshwari, LJ Dwyer, RF Sîrbulescu - Neurobiology of disease, 2023 - Elsevier
Acute injury to the central nervous system (CNS) remains a complex and challenging clinical
need. CNS injury initiates a dynamic neuroinflammatory response, mediated by both …

[HTML][HTML] Traumatic brain injury-induced inflammatory changes in the olfactory bulb disrupt neuronal networks leading to olfactory dysfunction

X Liu, Z Lei, D Gilhooly, J He, Y Li, RM Ritzel… - Brain, Behavior, and …, 2023 - Elsevier
Abstract Approximately 20–68% of traumatic brain injury (TBI) patients exhibit trauma-
associated olfactory deficits (OD) which can compromise not only the quality of life but also …

Microglial–oligodendrocyte interactions in myelination and neurological function recovery after traumatic brain injury

S Song, MN Hasan, L Yu, SS Paruchuri… - Journal of …, 2022 - Springer
Differential microglial inflammatory responses play a role in regulation of differentiation and
maturation of oligodendrocytes (OLs) in brain white matter. How microglia–OL crosstalk is …

Immune regulatory functions of macrophages and microglia in central nervous system diseases

M Poppell, G Hammel, Y Ren - International Journal of Molecular …, 2023 - mdpi.com
Macrophages can be characterized as a very multifunctional cell type with a spectrum of
phenotypes and functions being observed spatially and temporally in various disease states …