Intravenous fluid administration should be considered as any other pharmacological
prescription. There are three main indications: resuscitation, replacement, and maintenance …

Ventilator-free days (VFDs) are a commonly reported composite outcome measure in acute
respiratory distress syndrome trials. VFDs combine survival and duration of ventilation in a …

Sepsis is a life-threatening organ dysfunction that results from the body's response to
infection. It requires prompt recognition, appropriate antibiotics, careful hemodynamic …

Objective To identify research priorities in the management, epidemiology, outcome and
underlying causes of sepsis and septic shock. Design A consensus committee of 16 …

Perioperative organ injury is among the leading causes of morbidity and mortality of surgical
patients. Among different types of perioperative organ injury, acute kidney injury occurs …

Sepsis-associated acute kidney injury (S-AKI) is a common, life-threatening complication in
hospitalized and critically ill patients. S-AKI increases in-hospital mortality 6-fold to 8-fold, 1 …

Sepsis is a highly complex and lethal syndrome with highly heterogeneous clinical
manifestations that makes it difficult to detect and treat. It is also one of the major and most …

Clinical and pathophysiological understanding of septic shock has progressed exponentially
in the previous decades, translating into a steady decrease in septic shock-related morbidity …

Purpose Sepsis is a heterogeneous syndrome and identification of sub-phenotypes is
essential. This study used trajectories of vital signs to develop and validate sub-phenotypes …

Early management of sepsis and septic shock is crucial for patients' prognosis. As the
Emergency Department (ED) is the place where the first medical contact for septic patients is …