Stroke is a devastating condition with significant morbidity and mortality worldwide.
Antithrombotic therapy plays a crucial role in both primary and secondary prevention of …

• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

Patients with atrial fibrillation (AF) experiencing ischemic stroke despite oral anticoagulation
(OAC), ie, breakthrough strokes, are not uncommon, and represent an important clinical …

Background Chronic kidney disease (CKD) is a risk factor for embolic stroke, and many
nonvalvular atrial fibrillation (NVAF) patients have concomitant CKD. Anticoagulation …

A significant proportion of patients who suffer from atrial fibrillation (AF) and are in need of
thromboembolic protection are not treated with oral anticoagulation or discontinue this …

Intraprocedural stroke is a well-documented and feared potential risk of cardiovascular
transcatheter procedures (TPs). Moreover, subclinical neurological events or covert central …

Background Clinical outcomes of left atrial appendage occlusion (LAAO) combined with
other cardiac procedures have not been previously examined. Objectives This study sought …

Background Intracardiac echocardiography (ICE) is increasingly used during left atrial
appendage occlusion (LAAO) as an alternative to transesophageal echocardiography …

Left atrial appendage occlusion (LAAO) is a suitable alternative to oral anticoagulant therapy
to prevent stroke in patients with AF. Most procedures are performed under …

Abstract Background The Food and Drug Administration approved the Amulet occluder
(Abbott) after demonstrating safety and effectiveness in the Amulet IDE (AMPLATZER …