ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

TYROBP (also known as DAP12 or KARAP) is a transmembrane adaptor protein initially
described as a receptor-activating subunit component of natural killer (NK) cells. TYROBP is …

The existence of a selective blood-brain barrier (BBB) and neurovascular coupling are two
unique central nervous system vasculature features that result in an intimate relationship …

Drug addiction is a chronic and debilitating disease that is considered a global health
problem. Various cell types in the brain are involved in the progression of drug addiction …

Introduction The inositol polyphosphate‐5‐phosphatase D (INPP5D) gene encodes a dual‐
specificity phosphatase that can dephosphorylate both phospholipids and phosphoproteins …

Alzheimer's disease (AD) is a progressive neurodegenerative disease and is closely
associated with the accumulation of β-amyloid (Aβ) and neurofibrillary tangles (NFTs). Apart …

The commonalities and differences in cell-type-specific pathways that lead to Alzheimer
disease (AD) and Parkinson disease (PD) remain unknown. Here, we performed a single …

Alzheimer's disease (AD) is characterised by synaptic dysfunction accompanied by the
microscopically visible accumulation of pathological protein deposits and cellular dystrophy …

Abstract Apolipoprotein E4 (apoE4) is a risk factor for Alzheimer's disease (AD). Here, we
investigated brain amyloid-β (Aβ) accumulation throughout the aging process in an amyloid …

Circulating tumor cells (CTCs) play a key role in tumor metastasis. CTCs have altered gene
expression and can survive in the bloodstream. Finding the key genes whose expression …