The relationship between adiposity and breast cancer risk and prognosis is complex, with
associations that differ depending on when body size is assessed (eg, pre-vs …

Background Obesity and other metabolic comorbidities affect over 10% of patients with
breast cancer and are closely related with adverse outcomes. Although metabolic …

The enzyme aromatase (CYP19; cytochrome P450 19) in humans undergoes highly tissue-
and promoter-specific regulation. In hormone-dependent breast cancer, aromatase is over …

In breast adipose tissue, macrophages that encircle damaged adipocytes form “crown-like
structures of breast”(CLS-B). Although CLS-B have been associated with breast cancer, their …

Molecular subtype (MS) is one of the most used classifications of breast cancer (BC). Four
MSs are widely accepted according to receptor expression of estrogen, progesterone, and …

Prader-Willi syndrome (PWS) is a rare neuroendocrine genetic syndrome. Characteristics of
PWS include hyperphagia, hypotonia, and intellectual disability. Pituitary hormone …

Adipose tissue stores excess energy and produces a broad range of factors that regulate
multiple physiological processes including systemic energy homeostasis. Visceral adipose …

Aromatase is the enzyme responsible for converting testosterone to estradiol. In mammals,
aromatase is expressed in the testes, ovaries, brain, and other tissues. While estrogen is …

The emergence of megascale single-cell multiplex tissue imaging (MTI) datasets
necessitates reproducible, scalable, and robust tools for cell phenotyping and spatial …

Inflammation of the adipose tissues occurs in association with obesity. This inflammatory
process leads to the induction of cyclooxygenase-2 (COX-2) expression and a consequent …