Adverse outcome pathways (AOPs), introduced in modern toxicology, intend to provide an
evidence-based representation of toxicological effects and facilitate safety assessment of …

Obesity is a known risk factor for postmenopausal breast cancer; it has been postulated that
adipocytokines may mediate this association. We explored the relationship between three …

Purpose We investigated the effect of metformin and lifestyle intervention on metabolic,
inflammatory, and steroid biomarkers of breast cancer (BC) recurrence risk in two …

Objectives There is evidence that androgens are breast protective and that testosterone
therapy treats many symptoms of hormone deficiency in both pre and postmenopausal …

Several studies report that breast cancer survivors (BCS) tend to have a poor diet, as fruit,
vegetable, and legume consumption is often reduced, resulting in a decreased intake of …

Ovarian cancer risk factors differ by histotype; however, within subtype, there is substantial
variability in outcomes. We hypothesized that risk factor profiles may influence tumor …

The activity of the steroidogenic acute regulatory (StAR) protein is indispensable and rate
limiting for high output synthesis of steroid hormones in the adrenal cortex and the gonads …

Purpose: To determine if the degree of estrogen suppression with aromatase inhibitors (AI:
anastrozole, exemestane, letrozole) is associated with efficacy in early-stage breast cancer …

Aromatase is the rate-limiting enzyme in the biosynthesis of estrogens, which play crucial
roles on a spectrum of developmental and physiological processes. The biological actions of …

Objective To assess the impact of weight changes on the onset of puberty in overweight
children. Study design We evaluated the timing of puberty onset in 160 prepubertal …