Advances in nuclear proteostasis of metazoans
The proteostasis network and associated protein quality control (PQC) mechanisms ensure
proteome functionality and are essential for cell survival. A distinctive feature of eukaryotic …
proteome functionality and are essential for cell survival. A distinctive feature of eukaryotic …
Critical Cellular Functions and Mechanisms of Action of the RNA Helicase UAP56
R Yellamaty, S Sharma - Journal of Molecular Biology, 2024 - Elsevier
Posttranscriptional maturation and export from the nucleus to the cytoplasm are essential
steps in the normal processing of many cellular RNAs. The RNA helicase UAP56 (U2AF …
steps in the normal processing of many cellular RNAs. The RNA helicase UAP56 (U2AF …
The GC-content at the 5′ ends of human protein-coding genes is undergoing mutational decay
Background In vertebrates, most protein-coding genes have a peak of GC-content near their
5′ transcriptional start site (TSS). This feature promotes both the efficient nuclear export …
5′ transcriptional start site (TSS). This feature promotes both the efficient nuclear export …
Evolution of retrocopies in the context of HUSH silencing
J Kozłowska-Masłoń, J Ciomborowska-Basheer… - Biology Direct, 2024 - Springer
Retrotransposition is one of the main factors responsible for gene duplication and thus
genome evolution. However, the sequences that undergo this process are not only an …
genome evolution. However, the sequences that undergo this process are not only an …
NXT2 is the key player for nuclear RNA export in the human testis and critical for spermatogenesis
AK Dicke, A Ahmedani, L Ma, GW van der Heijden… - medRxiv, 2024 - medrxiv.org
In eukaryotes, the nucleocytoplasmic export of bulk poly (A)+-mRNAs through the nuclear
pore complex is mediated by the ubiquitously expressed NXT1-NXF1 heterodimer. In …
pore complex is mediated by the ubiquitously expressed NXT1-NXF1 heterodimer. In …
eIF4E orchestrates mRNA processing, RNA export and translation to modify specific protein production
The eukaryotic translation initiation factor eIF4E acts as a multifunctional factor that
simultaneously influences mRNA processing, export, and translation in many organisms. Its …
simultaneously influences mRNA processing, export, and translation in many organisms. Its …
Flawed machine-learning confounds coding sequence annotation
DJ Champion, TH Chen, S Thomson, MA Black… - bioRxiv, 2024 - biorxiv.org
Background Detecting protein coding genes in genomic sequences is a significant
challenge for understanding genome functionality, yet the reliability of bioinformatic tools for …
challenge for understanding genome functionality, yet the reliability of bioinformatic tools for …