CD98hc is a target for brain delivery of biotherapeutics
KS Chew, RC Wells, A Moshkforoush, D Chan… - nature …, 2023 - nature.com
Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-
brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport …
brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport …
[HTML][HTML] The solute carrier SLC7A1 may act as a protein transporter at the blood-brain barrier
M Kurtyka, F Wessely, S Bau, E Ifie, L He… - European Journal of …, 2024 - Elsevier
Despite extensive research, targeted delivery of substances to the brain still poses a great
challenge due to the selectivity of the blood-brain barrier (BBB). Most molecules require …
challenge due to the selectivity of the blood-brain barrier (BBB). Most molecules require …
Receptor-mediated transcytosis for brain delivery of therapeutics: receptor classes and criteria
AS Haqqani, K Bélanger, DB Stanimirovic - Frontiers in Drug Delivery, 2024 - frontiersin.org
The delivery of therapeutics into the brain is highly limited by the blood-brain barrier (BBB).
Although this is essential to protect the brain from potentially harmful material found in the …
Although this is essential to protect the brain from potentially harmful material found in the …
The proteome of the blood–brain barrier in rat and mouse: highly specific identification of proteins on the luminal surface of brain microvessels by in vivo glycocapture
TL Tremblay, W Alata, J Slinn, E Baumann… - Fluids and Barriers of …, 2024 - Springer
Background The active transport of molecules into the brain from blood is regulated by
receptors, transporters, and other cell surface proteins that are present on the luminal …
receptors, transporters, and other cell surface proteins that are present on the luminal …
Highly conserved brain vascular receptor ALPL mediates transport of engineered viral vectors across the blood-brain barrier
Delivery of systemically administered therapeutics to the central nervous system (CNS) is
restricted by the blood-brain barrier (BBB). Bioengineered Adeno-Associated Virus (AAV) …
restricted by the blood-brain barrier (BBB). Bioengineered Adeno-Associated Virus (AAV) …
Upregulation of Transferrin Receptor 1 (TfR1) at the Blood‐Brain Barrier by Valproic Acid, but Not of Glucose Transporter 1 (GLUT1) or CD98hc
MS Thomsen, KB Johnsen, LG Routhe… - 2024 - preprints.org
Background. Transferrin receptor 1 (TfR1), glucose transporter 1 (GLUT1), and CD98hc are
candidates for targeted therapy at the blood-brain barrier (BBB). Our objective was to …
candidates for targeted therapy at the blood-brain barrier (BBB). Our objective was to …
[PDF][PDF] Epigenetic upregulation by valproic acid of transferrin receptor 1, and not glucose transporter 1 or CD98hc, at the blood-brain barrier
SS Helgudóttir, KB Johnsen, LJ Routhe… - 2022 - scholar.archive.org
Background The objectives of the present study were to investigate whether the expression
of transferrin receptor 1 (TfR1), glucose transporter 1 (Glut1), or Cluster of Differentiation 98 …
of transferrin receptor 1 (TfR1), glucose transporter 1 (Glut1), or Cluster of Differentiation 98 …