(CVD) in individuals with type 1 diabetes mellitus (T1DM), the pathophysiology underlying
the relationship between cardiovascular events, CVD risk factors, and T1DM is not well …

The prevalence of type 2 diabetes (T2D) has increased worldwide and doubled over the last
two decades. It features among the top 10 causes of mortality and morbidity in the world …

Platelets are key players in the thrombotic processes. The alterations of platelet function due
to the occurrence of metabolic disorders contribute to an increased trend to thrombus …

Although the increased risk of pre-mature heart disease in type 1 diabetes has been
recognized for some time, the underlying pathogenesis is still poorly understood. The most …

Diabetic nephropathy (DN) is one of the major microvascular complications of diabetes and
it is defined as a rise in the urinary albumin excretion (UAE) rate and abnormal renal …

Diabetic nephropathy (DN) is a serious complication of diabetes caused by changes in the
structure and function of the kidneys. It is important to detect diagnostic biomarkers of DN at …

Although high glucose is an important contributor to diabetic vasculopathies, complications
still occur in spite of tight glycemic control, suggesting that some critical event prior to or …

Platelets' foremost role in survival is hemostasis. However, a significant quantity of research
has demonstrated that platelets are an integral part of inflammation and can also be potent …

CD40 ligand (CD40L) and its receptor CD40 participate in numerous inflammatory pathways
that contribute to multiple pathophysiological processes. A role for CD40–CD40L …

Disrupting the CD40-CD40L co-stimulatory pathway reduces atherosclerosis and induces a
stable atherosclerotic plaque phenotype that is low in inflammation and high in fibrosis …