In 1878, Billroth discovered that tumor cells invest themselves in a fibrin thrombus, and he
hypothesized that fibrin promotes tumor growth and invasion. Since then, many observations …

The main cause of cancer-related mortality, metastasis, is a complex, multi-step process.
The extracellular matrix (ECM) component of solid tumors has been implicated in metastatic …

The identification of stem-cell-like cancer cells through conventional methods that depend
on stem cell markers is often unreliable. We developed a mechanical method for selecting …

Fibrin is a major component of the provisional extracellular matrix formed during tissue
repair following injury, and enables cell infiltration and anchoring at the wound site …

Purpose Venous thromboembolism (VTE) is a well-recognized complication of cancer.
Laboratory parameters might be useful to assess the VTE risk in patients with cancer. The …

Weak immunogenicity of tumor cells is a root cause for the ultimate failure of
immunosurveillance and immunotherapy. Although tumor evolution can be shaped by …

To explore the role of the key coagulation factor, fibrinogen, in development, hemostasis,
wound repair, and disease pathogenesis, we disrupted the fibrinogen A alpha chain gene in …

Over the past two decades, many types of natural and synthetic polymer-based micro-and
nanocarriers, with exciting properties and applications, have been developed for application …

Dormancy is recognized as a critical biological event for tumorigenic cells surviving in an
extremely harsh environment. Understanding the molecular process of dormancy can unlock …

Experimental and clinical studies have shown an anticancer effect of anticoagulant drugs.
The aim of this study is to review the mechanisms by which the common types of …