Bipolar disorders
Bipolar disorders are a complex group of severe and chronic disorders that includes bipolar
I disorder, defined by the presence of a syndromal, manic episode, and bipolar II disorder …
I disorder, defined by the presence of a syndromal, manic episode, and bipolar II disorder …
The genetics of bipolar disorder
FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …
Novel Alzheimer disease risk loci and pathways in African American individuals using the African genome resources panel: a meta-analysis
Importance Compared with non-Hispanic White individuals, African American individuals
from the same community are approximately twice as likely to develop Alzheimer disease …
from the same community are approximately twice as likely to develop Alzheimer disease …
Genetics of bipolar disorder
N Craddock, P Sklar - The Lancet, 2013 - thelancet.com
Studies of families and twins show the importance of genetic factors affecting susceptibility to
bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and …
bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and …
Genome-wide association study reveals two new risk loci for bipolar disorder
TW Mühleisen, M Leber, TG Schulze… - Nature …, 2014 - nature.com
Bipolar disorder (BD) is a common and highly heritable mental illness and genome-wide
association studies (GWAS) have robustly identified the first common genetic variants …
association studies (GWAS) have robustly identified the first common genetic variants …
Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia
Bipolar disorder and schizophrenia are two often severe disorders with high heritabilities.
Recent studies have demonstrated a large overlap of genetic risk loci between these …
Recent studies have demonstrated a large overlap of genetic risk loci between these …
Improved detection of common variants associated with schizophrenia and bipolar disorder using pleiotropy-informed conditional false discovery rate
Several lines of evidence suggest that genome-wide association studies (GWAS) have the
potential to explain more of the “missing heritability” of common complex phenotypes …
potential to explain more of the “missing heritability” of common complex phenotypes …
Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
Bipolar disorder (BD) is a genetically complex mental illness characterized by severe
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have …
oscillations of mood and behaviour. Genome-wide association studies (GWAS) have …