Although much progress has been made in the fight against malaria, the number of people
that contract this disease due to the bite of an Anopheline mosquito remains unacceptably …

Despite global eradication efforts over the past century, malaria remains a devastating
public health burden, causing almost half a million deaths annually (WHO,). A detailed …

Mosquitoes serve as the obligate vectors for the transmission of malaria parasites. During its
sexual life cycle within the mosquito, the parasite must undergo several morphological …

Background Clinically protective malaria vaccines consistently fail to protect adults and
children in endemic settings, and at best only partially protect infants. Methodology/Principal …

Malaria is a serious, complex disease caused by parasites of the genus Plasmodium.
Plasmodium parasites affect multiple tissues as they evade immune responses, replicate …

In the Plasmodium life cycle, two infectious stages of parasites, merozoites and sporozoites,
share rhoptry and microneme apical structures. A crucial step during merozoite invasion of …

Plasmodium sporozoites are transmitted to mammals by anopheline mosquitoes and first
infect the liver, where they transform into replicative exoerythrocytic forms, which …

Background DNA microarrays have been a valuable tool in malaria research for over a
decade but remain in limited use in part due their relatively high cost, poor availability, and …

Upregulated in infectious sporozoites gene 4 (UIS4) encodes a parasitophorous vacuole
membrane protein expressed in the sporozoite and liver stages of rodent malaria parasites …

Malaria is caused by the unicellular apicomplexan parasites of the genus Plasmodium,
some of which, including the major human parasite Plasmodium falciparum, have extreme …