The ribosomal small subunit locus has been used for transgene expression in the rodent
malaria parasites, Plasmodium berghei and Plasmodium yoelii, but this strategy utilizes …

This chapter examines the biology of the infectious gametocyte in the vertebrate host, of the
sexual and sporogonic development in the mosquito vectors, and of the delivery of infectious …

Plasmodium sporozoites are infective forms of the parasite to mammalian hepatocytes.
Sporozoite surface or secreted proteins likely play an important role in recognition, invasion …

Seventy-five years ago, J. Gordon Thomson addressed the Royal Society of Tropical
Medicine and Hygiene on the topic of immunity in malaria (102). In introducing the subject …

The identification of surface proteins of the sporozoite stage of malaria parasites important
for sporozoite infectivity could aid in the improvement of the efficacy of vaccines targeting pre …

During invasion, Plasmodium parasites secrete proteins from rhoptry and microneme apical
end organelles, which have crucial roles in attaching to and invading target cells. A …

In the most important protozoan tropical diseases–malaria, leishmaniosis, sleeping sickness
and Chagas disease–the parasites are transmitted to humans by specific vectors: the …

Plasmodium sporozoites and liver stages express antigens that are targeted to the MHC-
Class I antigen-processing pathway. After the introduction of Plasmodium sporozoites by …

Mosquitoes are responsible for the transmission of pathogens that cause disease in over
400 million people each year worldwide. The capacity to transmit disease-causing …

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