The blood vessels vascularizing the central nervous system exhibit a series of distinct
properties that tightly control the movement of ions, molecules, and cells between the blood …

The blood-brain barrier (BBB) plays a vital role in regulating the trafficking of fluid, solutes
and cells at the blood-brain interface and maintaining the homeostatic microenvironment of …

Alzheimer's disease (AD) is the most common form of dementia. AD brain pathology starts
decades before the onset of clinical symptoms. One early pathological hallmark is blood …

The mechanism and long-term consequences of early blood–brain barrier (BBB) disruption
after cerebral ischaemic/reperfusion (I/R) injury are poorly understood. Here we discover …

Mitochondria are a major target in hypoxic/ischemic injury. Mitochondrial impairment
increases with age leading to dysregulation of molecular pathways linked to mitochondria …

The aging of the central nervous system and the development of incapacitating neurological
diseases like Alzheimer's disease (AD) are generally associated with a wide range of …

The retinal and cerebral microvasculatures share many morphological and physiological
properties. Assessment of the cerebral microvasculature requires highly specialized and …

Aging is a complex biological process that increases the risk of age-related cognitive
degenerative diseases such as dementia, including Alzheimer's disease (AD), Lewy Body …

Brain endothelial cells (BECs) are key constituents of the blood-brain barrier (BBB),
protecting the brain from pathogens and restricting access of circulatory factors. Yet …

Chronic cerebral hypoperfusion has been associated with cognitive decline in aging and
Alzheimer's disease. Moreover, the pattern of cerebral blood flow in mild cognitive …