Depression is a heterogeneous and etiologically complex psychiatric syndrome, not a
unitary disease entity, encompassing a broad spectrum of psychopathology arising from …

Research into major depressive disorder (MDD) is complicated by population heterogeneity,
which has motivated the search for more homogeneous subtypes through data-driven …

The surgical management of brain tumors is based on the principle that the extent of
resection improves patient outcomes. Traditionally, neurosurgeons have considered that …

The neural substrates of depression may differ in men and women, but the underlying
mechanisms are incompletely understood. Here, we show that depression is associated with …

Cluster analyzes have been widely used in mental health research to decompose inter-
individual heterogeneity by identifying more homogeneous subgroups of individuals …

Depression is a highly heterogeneous syndrome that bears only modest correlations with its
biological substrates, motivating a renewed interest in rethinking our approach to …

The search for more effective treatments for depression is a long-standing primary objective
in both psychiatry and translational neuroscience. From initial models centered on …

There is an urgent need to derive quantitative measures based on coherent neurobiological
dysfunctions or 'biotypes' to enable stratification of patients with depression and anxiety. We …

Many studies have highlighted the difficulty inherent to the clinical application of
fundamental neuroscience knowledge based on machine learning techniques. It is difficult …

Major depressive disorder (MDD) has been characterized by structural abnormalities of
multiple brain regions. Nevertheless, little is known about the underlying neuropathological …