Apigenin induces autophagy and cell death by targeting EZH2 under hypoxia conditions in gastric cancer cells

TW Kim, HG Lee - International Journal of Molecular Sciences, 2021 - mdpi.com
Hypoxia is a major obstacle to gastric cancer (GC) therapy and leads to chemoresistance as
GC cells are frequently exposed to the hypoxia environment. Apigenin, a flavonoid found in …

2-Benzhydrylsulfinyl-N-hydroxyacetamide-Na extracted from fig as a novel cytotoxic and apoptosis inducer in SKOV-3 and AMJ-13 cell lines via P53 and caspase-8 …

HNK Al-Salman, ET Ali, M Jabir, GM Sulaiman… - European food research …, 2020 - Springer
In this study, the fruits of both mature and air-dried figs were exposed to selective sequential
extracting processes using soxhlet. Different polarity and non-polarity solvents were used to …

Plant secondary metabolites: an introduction of their chemistry and biological significance with physicochemical aspect

A Sharma, S Sharma, A Kumar, V Kumar… - … -chemical properties and …, 2022 - Springer
Nature is the immense source of chemical compounds or substances usually acknowledged
as natural products. Plants are the considerable source of an inestimable diversity of natural …

Recent advances in flavonoid-based nanocarriers as an emerging drug delivery approach for cancer chemotherapy

S Dewanjee, P Chakraborty, H Bhattacharya… - Drug Discovery …, 2023 - Elsevier
Highlights•Flavonoids exhibit therapeutic potential against different types of cancer
cells.•Poor pharmacokinetics and biopharmaceutical traits limit their therapeutic …

Molecular mechanisms of flavonoids in melanin synthesis and the potential for the prevention and treatment of melanoma

F Liu‐Smith, FL Meyskens - Molecular nutrition & food research, 2016 - Wiley Online Library
Flavonoids are becoming popular nutraceuticals. Different flavonoids show similar or distinct
biological effects on different tissues or cell types, which may limit or define their usefulness …

Glutathione, an antioxidant tripeptide: dual roles in carcinogenesis and chemoprevention

A Narayanankutty, JT Job… - Current Protein and …, 2019 - ingentaconnect.com
Glutathione (GSH or reduced glutathione) is a tripeptide of gamma-Glutamyl-
cysteinylglycine and the predominant intracellular antioxidant in many organisms including …

Quercetin inhibits human metastatic ovarian cancer cell growth and modulates components of the intrinsic apoptotic pathway in PA-1 cell line

D Teekaraman, SP Elayapillai, MP Viswanathan… - Chemico-biological …, 2019 - Elsevier
Ovarian cancer is the leading cause of gynaecology related cancer death worldwide. It is
often diagnosed with an advanced stage. Apoptosis is a process of programmed cell death …

The complex interplay between chronic inflammation, the microbiome, and cancer: understanding disease progression and what we can do to prevent it

H Armstrong, M Bording-Jorgensen, S Dijk, E Wine - Cancers, 2018 - mdpi.com
Cancer is a multifaceted condition, in which a senescent cell begins dividing in an irregular
manner due to various factors such as DNA damage, growth factors and inflammation …

Advances in alkynyl gold complexes for use as potential anticancer agents

Z Yang, G Jiang, Z Xu, S Zhao, W Liu - Coordination Chemistry Reviews, 2020 - Elsevier
Gold-based anticancer agents have gained the widespread attention of medicinal inorganic
chemists due to their unique chemical properties and strong antiproliferative potency …

Flavonoids: New frontier for immuno-regulation and breast cancer control

M Sudhakaran, S Sardesai, AI Doseff - Antioxidants, 2019 - mdpi.com
Breast cancer (BC) remains the second most common cause of cancer-related deaths in
women in the US, despite advances in detection and treatment. In addition, breast cancer …