Current status and future trends of the global burden of MASLD

L Miao, G Targher, CD Byrne, YY Cao… - Trends in Endocrinology & …, 2024 - cell.com
Metabolic dysfunction-associated steatotic liver disease (MASLD) has emerged as the most
common chronic liver disease globally, affecting more than a third of the world's adult …

FXR agonists for MASH therapy: Lessons and perspectives from obeticholic acid

K Wang, Y Zhang, G Wang, H Hao… - Medicinal Research …, 2024 - Wiley Online Library
Nonalcoholic fatty liver disease, also called metabolic dysfunction‐associated steatotic liver
disease, is the most common liver disease worldwide and has no approved …

Antioxidant peptides from monkfish swim bladders: ameliorating NAFLD in vitro by suppressing lipid accumulation and oxidative stress via regulating AMPK/Nrf2 …

MF Wu, QH Xi, Y Sheng, YM Wang, WY Wang, CF Chi… - Marine drugs, 2023 - mdpi.com
In this study, we investigate the ameliorating functions of QDYD (MSP2), ARW (MSP8),
DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) from monkfish swim bladders on …

Breaking the barriers: the role of gut homeostasis in Metabolic-Associated Steatotic Liver Disease (MASLD)

R Benedé-Ubieto, FJ Cubero, YA Nevzorova - Gut microbes, 2024 - Taylor & Francis
ABSTRACT Obesity, insulin resistance (IR), and the gut microbiome intricately interplay in
Metabolic-associated Steatotic Liver Disease (MASLD), previously known as Non-Alcoholic …

The coumarin-derivative esculetin protects against lipotoxicity in primary rat hepatocytes via attenuating jnk-mediated oxidative stress and attenuates free fatty acid …

M Xia, Z Wu, J Wang, M Buist-Homan, H Moshage - Antioxidants, 2023 - mdpi.com
Coumarin derivates have been proposed as a potential treatment for metabolic-dysfunction-
associated fatty liver disease (MAFLD). However, the mechanisms underlying their …

The role of anti-diabetic drugs in NAFLD. Have we found the Holy Grail? A narrative review

M Zachou, P Flevari, N Nasiri-Ansari… - European Journal of …, 2024 - Springer
Purpose Non-alcoholic fatty liver disease (NAFLD) has become a leading cause of liver
disease, affecting 30% of the global population. NAFLD prevalence is particularly high in …

The janus-faced role of lipid droplets in aging: insights from the cellular perspective

N Bresgen, M Kovacs, A Lahnsteiner, TK Felder… - Biomolecules, 2023 - mdpi.com
It is widely accepted that nine hallmarks—including mitochondrial dysfunction, epigenetic
alterations, and loss of proteostasis—exist that describe the cellular aging process. Adding …

[HTML][HTML] The prospect of non-alcoholic fatty liver disease in adult patients with metabolic syndrome: a systematic review

Z Zohara, A Adelekun, KD Seffah, K Salib, L Dardari… - Cureus, 2023 - ncbi.nlm.nih.gov
In recent years, there has been an increasing trend in the development of non-alcoholic fatty
liver disease (NAFLD) due to lifestyle changes. The limited treatment option for the disease …

Raspberry ketone ameliorates nonalcoholic fatty liver disease in rats by activating the AMPK pathway

ME Askar, SI Ali, NN Younis, MA Shaheen… - European Journal of …, 2023 - Elsevier
The current study aimed to investigate the effect of orally administered raspberry ketone
(RK) on ameliorating nonalcoholic fatty liver disease (NAFLD) induced in rats by high-fat …

Effect of isoquercitrin on free fatty acid-induced lipid accumulation in HepG2 cells

SH Kim, C Yun, D Kwon, YH Lee, JH Kwak, YS Jung - Molecules, 2023 - mdpi.com
Liver metabolic disorders and oxidative stress are crucial factors in the development of
nonalcoholic fatty liver disease (NAFLD); however, treatment strategies to combat NAFLD …