Mutations of the BRCA1 tumor suppressor gene are the most commonly detected alterations
in familial breast and ovarian cancer. Although BRCA1 is required for normal mouse …

The transition from a normal cell to a neoplastic cell is a complex process and involves both
genetic and epigenetic changes. The process of carcinogenesis begins when the DNA is …

The importance of Bax for induction of tumor apoptosis through death receptors remains
unclear. Here we show that Bax can be essential for death receptor–mediated apoptosis in …

The tumor suppressor gene p53 plays a major role in regulation of the mammalian cellular
stress response, in part through the transcriptional activation of genes involved in cell cycle …

Anti‐tumour therapies based on the use pro‐apoptotic receptor agonists, including TNF‐
related apoptosis‐inducing ligand (TRAIL) or monoclonal antibodies targeting TRAIL‐R1 or …

P53 is known as the most critical tumor suppressor and is often referred to as the guardian of
our genome. More than 40 years after its discovery, we are still struggling to understand all …

Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic
development, growth, and metastatic dissemination in a process called cancer …

The tumour suppressor p53 is a central player in cellular DNA damage responses. P53 is
upregulated and activated by genotoxic stress and induces a transcriptional programme with …

Wild-type p53 is a tumor suppressor gene which can activate or repress transcription, as
well as induce apoptosis. The human p53 proline-rich domain localized between amino …

The tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) induces apoptosis of
tumor cells but not normal cells; its role in normal nontransformed tissues is unknown. We …